Androgen Levels in the Third Trimester of Pregnancy in Patients with Preeclampsia | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 52, Volume 95, Issue 1, April 2024, Page 1625-1629 PDF (356.33 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2024.352202 | ||||
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| Abstract | ||||
| Background: Although the aetiology of pre-eclampsia is not entirely known, numerous theories have been put in relation to its causes. Finding its risk factors is crucial because to its morbid course. However, because to a lack of information regarding its origin, numerous studies have been conducted on a variety of materials in an effort to identify its causes. One of these ideas focuses on the underlying endocrine changes and quantification of different androgens. Objective: This study aimed to compare between androgens level (serum total and free testosterone) in women with preeclampsia and normal ones in the 3rd trimester of pregnancy (28-40 weeks). Patients and methods: During this study, 80 pregnant women were enrolled in this study. They were divided into two groups: Group A comprised 40 pregnant women in their 3rd trimester with preeclampsia at the time of admission, whereas group B consisted of 40 healthy normotensive women in their 3rd trimester who served as control group A with matched maternal age, gestational age, and BMI. Results: Our study revealed that free and total testosterone levels were significantly higher among pre-eclamptic cases compared to healthy women with no differences regarding maternal age, gestational age and fetal sex. Conclusion: Pre-eclamptic women had greater serum androgen levels (free and total testosterones) throughout the 3rd trimester of pregnancy, this may suggest that androgens have a role in the development of pre-eclampsia. | ||||
| Keywords | ||||
| Androgen; Third trimester of pregnancy; Preeclampsia | ||||
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