Modulatory Role of Zeolite against Cadmium Chloride-Induced Renal Damage In Pregnant Rats and Their Fetuses

Ibrahim, Nehad M.; Kandil, Asmaa M.; Ali, Rania S.; Ahmed, Hanan; Yahia, Rania

doi:10.21608/eajbsz.2024.352274

	Modulatory Role of Zeolite against Cadmium Chloride-Induced Renal Damage In Pregnant Rats and Their Fetuses
Egyptian Academic Journal of Biological Sciences, B. Zoology
Volume 16, Issue 1, June 2024, Page 157-170 PDF (1.09 MB)
Document Type: Original Article
DOI: 10.21608/eajbsz.2024.352274
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Authors
Nehad M. Ibrahim¹; Asmaa M. Kandil²; Rania S. Ali¹; Hanan Ahmed¹; Rania Yahia²
¹Zoology and Entomology Department, Faculty of Science, Helwan University, Egypt.
²Pharmacology Department, Egyptian Drug Authority, EDA, Formerly NODCAR, Giza, Egypt.
Abstract
Cadmium (Cd) is a heavy metal and a significant inorganic toxin that is commonly found throughout the environment. The human body, as well as the kidneys, tend to accumulate Cd. Research conducted on both humans and animals suggests that exposure to cadmium can lead to significant skeletal damage, specifically osteoporosis. Based on the prevalence of cadmium in the environment and its frequent use, we studied the effect of its toxicity on pregnant rat and their fetuses and the effect of zeolite on them. The experimental rats were divided into 5 groups (n=8, each). The 1^st group received distilled water as a normal control group. The 2^nd received tween⁸⁰and served as tween⁸⁰ group. The 3^rdwas administrated with zeolite dissolved in tween⁸⁰then in distilled water at a dose (100mg\kg\day). The 4^th was administrated with cadmium chloride at dose (30mg\kg\day). The 5^th was administrated with a combination of both zeolite and cadmium chloride. All groups were administered the materials orally from the 6^th day to the 15^th day of gestation. All animals were sacrificed at the end of gestation periods (on the 20^th day). Our obtained results showed adverse histological alterations in maternal and fetal kidneys. Also, CdCl₂ (cadmium chloride) induced remarkable changes in the levels of kidney functions. On the other hand, results showed incomplete ossification of the skull, metacarpals, and phalanges of the toes of fetuses’ skeletons. Zeolite administration markedly ameliorated the altered renal histological and physiological changes as well as the skeletal deformity in fetuses induced by cadmium.
Keywords
Teratology; cadmium chloride; zeolite; gestation; kidneys


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