Role Of Serum Hepcidin as A Diagnostic and Prognostic Marker For Sepsis among Critically ill Patients
Elsayed, A., El hendy, Y., Ehab, I., Amr, G., Afifi, A., Edwar, M., Ragab, U. (2024). Role Of Serum Hepcidin as A Diagnostic and Prognostic Marker For Sepsis among Critically ill Patients. EKB Journal Management System, (), -. doi: 10.21608/zumj.2024.285207.3354
Ahmed Noaman Elsayed; Yaser A A El hendy; Islam Ehab; Ghada Elsayed Amr; Amira Hamed Mohamed Afifi; Michael Edwar; Usama Ragab. "Role Of Serum Hepcidin as A Diagnostic and Prognostic Marker For Sepsis among Critically ill Patients". EKB Journal Management System, , , 2024, -. doi: 10.21608/zumj.2024.285207.3354
Elsayed, A., El hendy, Y., Ehab, I., Amr, G., Afifi, A., Edwar, M., Ragab, U. (2024). 'Role Of Serum Hepcidin as A Diagnostic and Prognostic Marker For Sepsis among Critically ill Patients', EKB Journal Management System, (), pp. -. doi: 10.21608/zumj.2024.285207.3354
Elsayed, A., El hendy, Y., Ehab, I., Amr, G., Afifi, A., Edwar, M., Ragab, U. Role Of Serum Hepcidin as A Diagnostic and Prognostic Marker For Sepsis among Critically ill Patients. EKB Journal Management System, 2024; (): -. doi: 10.21608/zumj.2024.285207.3354

Role Of Serum Hepcidin as A Diagnostic and Prognostic Marker For Sepsis among Critically ill Patients

Zagazig University Medical Journal
Articles in Press, Accepted Manuscript, Available Online from 29 April 2024  XML
Document Type: Original Article
DOI: 10.21608/zumj.2024.285207.3354
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Authors
Ahmed Noaman Elsayed1; Yaser A A El hendy2; Islam Ehab email 3; Ghada Elsayed Amrorcid 4; Amira Hamed Mohamed Afifiorcid 5; Michael Edwar3; Usama Ragaborcid 6
1Internal Medicine Department, Faculty of Medicine, Zagazig University, Egypt
2Internal medicine, faculty of medicine zagazig University zagazig Egypt
3Internal Medicine Department, Faculty of Medicine, Zagazig University
4Department of Clinical Pathology, Faculty of Medicine – Zagazig University, Egypt
5clinical pathology faculty of medicine zagazig univeristy
6Internal Medicine Department, Faculty of Medicine, Zagazig University, Egypt.
Abstract
Background: In the last decade hepcidin which was previously known to have a significant role in iron metabolism, has gained attention as a possible marker of bacterial sepsis in adults. This research aimed to evaluate the role of hepcidin as a biomarker for diagnosis and prognosis ‎of sepsis among critically ill patients.

Methods: In a cohort study, 62 emergency medical patients who were admitted to the ICU within 24 hours and were divided into two groups: those with sepsis (Group A) and those without (Group B). Hepcidin levels were measured using an ELISA kit, and patient assessments included SOFA, SAPS 3, and APACHE II scores.

Results: Septic patients had significantly higher hepcidin than the non-septic patients (p<0.001). Hepcidin was a significant diagnostic marker for sepsis with sensitivity (91.89%) and specificity (70.97%) at cutoff point of 2.52 ng/ml with AUC was (0.922). Multivariate regression analysis revealed that alongside traditional sepsis markers, hepcidin and SAPS3 scores were independent predictors of mortality, with ORs of 2.09 (95% CI: 1.31–3.33, p=0.002) and 1.21 (95% CI: 1.04–1.4, p=0.01), respectively.

Conclusion: Serum hepcidin, combined with clinical scoring systems, proves to be a reliable diagnostic tool for sepsis and could serve as a predictor of mortality in critically ill septic patients.
Keywords
Serum Hepcidin; Predictor; Mortality; Sepsis; critically ill
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