Validated Spectrophotometric Methods Based on Charge Transfer Complexation Reactions for the Quantification of Antimalarial Drug: Chloroquine Phosphate in Pure and Dosage Forms
Gouda, A., elsheikh, R., Gaber, S., Mahmoud, M., Abdel Allem, A., El Sayed, A., Ghazy, A. (2024). Validated Spectrophotometric Methods Based on Charge Transfer Complexation Reactions for the Quantification of Antimalarial Drug: Chloroquine Phosphate in Pure and Dosage Forms. EKB Journal Management System, 2024(1), 182-194. doi: 10.21608/bfszu.2023.235670.1308
Ayman A Gouda; Ragaa elsheikh; Sara Gaber; Moataz S. Mahmoud; Ahmed F Abdel Allem; Ahmed El Sayed; Ahmed Ghazy. "Validated Spectrophotometric Methods Based on Charge Transfer Complexation Reactions for the Quantification of Antimalarial Drug: Chloroquine Phosphate in Pure and Dosage Forms". EKB Journal Management System, 2024, 1, 2024, 182-194. doi: 10.21608/bfszu.2023.235670.1308
Gouda, A., elsheikh, R., Gaber, S., Mahmoud, M., Abdel Allem, A., El Sayed, A., Ghazy, A. (2024). 'Validated Spectrophotometric Methods Based on Charge Transfer Complexation Reactions for the Quantification of Antimalarial Drug: Chloroquine Phosphate in Pure and Dosage Forms', EKB Journal Management System, 2024(1), pp. 182-194. doi: 10.21608/bfszu.2023.235670.1308
Gouda, A., elsheikh, R., Gaber, S., Mahmoud, M., Abdel Allem, A., El Sayed, A., Ghazy, A. Validated Spectrophotometric Methods Based on Charge Transfer Complexation Reactions for the Quantification of Antimalarial Drug: Chloroquine Phosphate in Pure and Dosage Forms. EKB Journal Management System, 2024; 2024(1): 182-194. doi: 10.21608/bfszu.2023.235670.1308

Validated Spectrophotometric Methods Based on Charge Transfer Complexation Reactions for the Quantification of Antimalarial Drug: Chloroquine Phosphate in Pure and Dosage Forms

Bulletin of Faculty of Science, Zagazig University
Article 19, Volume 2024, Issue 1, April 2024, Page 182-194  XML PDF (868.98 K)
Document Type: Original Article
DOI: 10.21608/bfszu.2023.235670.1308
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Authors
Ayman A Gouda email 1; Ragaa elsheikh2; Sara Gaber2; Moataz S. Mahmoud2; Ahmed F Abdel Allem2; Ahmed El Sayed2; Ahmed Ghazy2
1Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt
2Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.
Abstract
Chloroquine phosphate (CQP), an antimalarial medication, has been determined using two straightforward, sensitive, quick, and verified spectrophotometric techniques. The procedures were based on the generation of charge transfer complexes in methanol utilizing alizarin red S (ARS) and quinalizarin (Quinz) as chromogenic reagents, respectively, with absorption maxima at 560 and 531 nm for each. Investigated was the optimization of the reaction conditions, including the kind of solvent, reagent concentration, and reaction time. Beer's law is effectively observed using Quinz and ARS, respectively, in the concentration ranges of 1.0-20 and 1.0-16 g mL-1, with strong correlation coefficients (r2 ≥0.9995) and low relative standard deviations (RSD%≤ 1.07). Calculations were also made for the molar absorptivity, Sandell sensitivity, detection, and quantification limitations. The approaches were successfully used to identify CQP in pharmaceutical formulations, and the standard addition technique. was used to evaluate the methods' validity. Results from the suggested procedures for pure CQP and dosage forms were in good agreement with those from the previously described approach.
Keywords
Chloroquine phosphate; Spectrophotometry; Charge transfer reaction; Dosage forms; Method validation
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