Exploring the Potential Hepatoprotective efficacy of Lepidium Sativum seeds: A Comprehensive Review | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Articles in Press, Accepted Manuscript, Available Online from 01 May 2024 | ||||
| Document Type: Review Article | ||||
| DOI: 10.21608/bfsa.2024.276705.2061 | ||||
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| Authors | ||||
Eman. S Sawan1; Alaa A. Abdelhadi2; Kareem H. Elsyed2; Nora H. Elsayed2; Heba R. Yassen2; Manar R. Mohammed2; Nadeen. S. Ahmed2; Manar K. Zahran2; Nada M. Elkest2; Omar Hammad2; Shimaa Shimaa Abdelsattar3; Raghda Hussein  4; Mohamed M. Abdel-Latif5; Shaza H. Aly6
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| 1Department of Clinical Pharmacy, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City 11829, Egypt | ||||
| 2Under graduate Students at Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City 11829, Egypt | ||||
| 3Department of Clinical Biochemistry and Molecular Diagnostics, National Liver Institute, Menofia University | ||||
| 4Clinical Pharmacy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt | ||||
| 5Department of Clinical Pharmacy, Faculty of Pharmacy, Assiut University | ||||
| 6Department of Pharmacognosy, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City 11829 | ||||
| Abstract | ||||
| Abstract: Background: Chronic liver diseases are the leading cause of morbidity and mortality worldwide.Lepidium sativum (L. sativum) is a famous member of the Bras-sicaceae family that has been utilized for medicinal and culinary purposes for cen-turies. The hepatoprotective activity of various portions of the plant has been re-ported in several experimental and clinical trials. Aim: The current review study aimed to discuss the hepatoprotective effects of L. sativum seeds. Methods: The da-ta of this review were collected from English-language in-vivo and in-vitro studies published in electronic databases; with no time limit; including Web of Science, Scopus, MEDLINE, Google Scholar and PubMed. The searched keywords were “Lepidium sativum” and/or “chemical composition”, “Hepatoprotective”, “liver diseases”. Results: Lepidium sativum seeds significantly decreased the elevated in-flammatory markers and oxidative stress in hepatic tissues. The seed extract signifi-cantly lowered serum levels of ASP, ALT, and bilirubin. The potential molecular mechanism may be through upregulating Bcl-2 protein expression and downregu-lating caspase-3. Conclusion: Lepidium sativum seeds are promising hepatoprotec-tive natural remedy through their multi-targeted action on different pathophysio-logical mechanisms involved in liver diseases. | ||||
| Keywords | ||||
| Lepidium sativum; Secondary metabolites; Hepatoprotective | ||||
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