Effect of ginger on gabapentin-induced morphological and skeletal abnormalities in the chick Gallus domestics
Badawy, G., Atallah, M., Sakr, S. (2023). Effect of ginger on gabapentin-induced morphological and skeletal abnormalities in the chick Gallus domestics. EKB Journal Management System, 27(1), 1-31. doi: 10.21608/sjfsmu.2023.353141
Gamal Badawy; Marwa Atallah; Saber Sakr. "Effect of ginger on gabapentin-induced morphological and skeletal abnormalities in the chick Gallus domestics". EKB Journal Management System, 27, 1, 2023, 1-31. doi: 10.21608/sjfsmu.2023.353141
Badawy, G., Atallah, M., Sakr, S. (2023). 'Effect of ginger on gabapentin-induced morphological and skeletal abnormalities in the chick Gallus domestics', EKB Journal Management System, 27(1), pp. 1-31. doi: 10.21608/sjfsmu.2023.353141
Badawy, G., Atallah, M., Sakr, S. Effect of ginger on gabapentin-induced morphological and skeletal abnormalities in the chick Gallus domestics. EKB Journal Management System, 2023; 27(1): 1-31. doi: 10.21608/sjfsmu.2023.353141

Effect of ginger on gabapentin-induced morphological and skeletal abnormalities in the chick Gallus domestics

Scientific Journal of Faculty of Science, Menoufia University
Contributors, Volume 27, Issue 1, December 2023, Page 1-31  XML PDF (943.78 K)
DOI: 10.21608/sjfsmu.2023.353141
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Authors
Gamal Badawyorcid 1; Marwa Atallah email 2; Saber Sakr3
1Professor at Zoology Department, faculty of science, Menoufia University
2Associate Professor at Zoology Department, Faculty of Science, Menoufia University.
3Professor at Zoology Department, Faculty of Science, Menoufia University
Abstract
Epilepsy is associated with an increased risk of having malformed children.
Gabapentin (GBP) is a new generation antiepileptic drug and categorized as ‘C’
considering its possible teratogenic risk. The present study adopted two integrated aspects.
The first has dealt with investigating the possible toxic side effects of GBP on the
developing chick embryos in terms of morphological and endo-skeletal studies. The second
examined the possible ameliorative effect of ginger water extract against the toxicity
induced by GBP injection. Injection of GBP resulted in adverse effects in chick embryos
at different levels. Morphologically, the chick embryos suffered from significant growth
retardation and various morphological malformations such as omphalocele, limb
deformities, short beak and subcutaneous hemorrhage. The endoskeleton showed different
alterations including kyphosis, caudal regression syndrome kinked tail and pygostyle, loss
of some bone. In addition, there was reduction in the ossification centers of long bones.
Co-injection of ginger along with GBP decreased the incidence of most morphological and
endo-sk0eletal alterations, furthermore, increased the length of ossification centers in long
bones compared with GBP alone. In conclusion, the use of GBP as an AED should be
treated with highly caution during pregnancy and ginger is recommended to be taken in
parallel for its ameliorative role in this regard.
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