ENDOCAN: A NOVEL BIOMARKER IN GINGIVAL CREVICULAR FLUID IN PERIODONTITIS PATIENTS WITH OR WITHOUT TYPE 2 DIABETES MELLITUS [A CROSS-SECTIONAL STUDY] | ||||
| Alexandria Dental Journal | ||||
| Articles in Press, Corrected Proof, Available Online from 05 May 2024 PDF (322.67 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/adjalexu.2023.201324.1360 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Emad Said Ayad  1; Maha Abd El Aziz Abou Khadr2; Mona Wagdy Ayad3; Gillan Ibrahim El-Kimary 4
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| 1Department of Oral Medicine, Periodontology, Oral Diagnosis and Oral Radiology, Faculty of Dentistry, Alexandria University, Alexandria ,Egypt | ||||
| 2Oral Medicine, Periodontology, Oral Diagnosis and Oral Radiology, Faculty of Dentistry, Alexandria University, Alexandria, Egypt. | ||||
| 3Clinical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt | ||||
| 4Lecturer of periodontology, Department of Oral Medicine, Periodontology, Oral Diagnosis and Radiology, Faculty of Dentistry, Alexandria University | ||||
| Abstract | ||||
| Background: Clinical parameters are used to diagnose periodontal disease. However, new technical advances in diagnostics for assessing periodontal status are utilizing objective biomarkers. Recently, a number of biomarkers have been identified to predict periodontitis status. Endocan is a novel pro-inflammatory biomarker that is thought to give an insight on periodontal disease status. Objective: Evaluation of Endocan level in gingival crevicular fluid (GCF) of stage 1 and 2 periodontitis patients with or without type 2 diabetes mellitus. Materials and Methods: 42 patients with stage 1 and 2 periodontitis were divided into two groups: 23 patients with controlled type 2 diabetes mellitus (CT2DM-P) and 19 systemically healthy periodontitis patients (H-P). Endocan level in GCF, periodontal parameters, and Hemoglobin A1c (HbA1c) value were measured. Biochemical analysis of Endocan level was performed by enzyme-linked immunosorbent assay (ELISA). Results: GCF Endocan level was significantly higher in the CT2DM-P group than in the H-P group. Mean pocket probing depth (PPD), clinical attachment loss (CAL), and bleeding on probing percentage (BOP%) were higher in the CT2DM-P group. Endocan was positively correlated to CAL, BOP%, and HbA1c in both groups, with Endocan and BOP% having a moderate correlation in the CT2DM-P group and Endocan and HbA1c having a strong correlation in the H-P group. Conclusion: Endocan levels, PPD, CAL, and BOP% in CT2DM-P group were higher than H-P group. Positive correlations between BOP%, Glycated hemoglobin and Endocan were also observed. | ||||
| Keywords | ||||
| Biomarkers; Diabetes Mellitus; Endocan; Gingival Crevicular Fluid; Periodontitis | ||||
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