CLINICAL EVALUATION OF ADJUNCTIVE ORAL SYSTEMIC VITAMIN E THERAPY IN PATIENTS WITH EROSIVE ORAL LICHEN PLANUS (A RANDOMIZED CONTROLLED CLINICALC TRIAL)

Shakir, Marwah Waleed; Adam, Fatma Amin; Gaweesh, Yasmin Youssri

doi:10.21608/adjalexu.2023.220174.1394

	CLINICAL EVALUATION OF ADJUNCTIVE ORAL SYSTEMIC VITAMIN E THERAPY IN PATIENTS WITH EROSIVE ORAL LICHEN PLANUS (A RANDOMIZED CONTROLLED CLINICALC TRIAL)
Alexandria Dental Journal
Articles in Press, Corrected Proof, Available Online from 05 May 2024 PDF (189.23 K)
Document Type: Original Article
DOI: 10.21608/adjalexu.2023.220174.1394
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Authors
Marwah Waleed Shakir ¹; Fatma Amin Adam²; Yasmin Youssri Gaweesh²
¹Oral medicine, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
²Oral Medicine, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
Abstract
Background: Oral lichen planus (OLP) is a chronic autoimmune disorder. It mostly involves the skin, mucous membrane, and rarely the scalp and nails. It is an inflammatory condition driven by T-cells. Traditional treatment for OLP is topical steroids, which are frequently used to treat lesions with mild to moderate symptoms. Recent treatment modalities for oral lichen planus include micronutrients as antioxidants, including vitamin E, that modify the immune system function. Aim of the study: The purpose of this study is to assess the clinical response to adjunctive oral systemic vitamin E therapy in erosive oral lichen planus patients. Materials and Methods: 50 patients participated in this randomized, controlled clinical study. The Erosive OLP patients were split into two parallel groups: 25 in group A, patients were administered oral systemic vitamin E adjunctive to topical corticosteroids. Group B: 25 patients received topical corticosteroids alone. Clinically, treatment responses were evaluated according to Thongprasom et al. scoring system before and after both treatment modalities. Results: After 4 and 8 weeks of treatment, there was a significant decline in the Thongprasom scores in the research groups. Both the mean score values for the outcomes after four and eight weeks were more prominent in the test group. Throughout the clinical experiment, the test and control groups were statistically different. Conclusion: For patients with erosive oral lichen planus, vitamin E might be an excellent therapy option.
Keywords
Vitamin E; erosive oral lichen planus; randomized-controlled clinical trial


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