Evaluation of Plasma D-Lactate Level in Preterm Infants with Necrotizing Enterocolitis | ||||
Ain Shams Medical Journal | ||||
Volume 75, Issue 1, March 2024, Page 81-88 PDF (443.61 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/asmj.2023.241216.1175 | ||||
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Authors | ||||
Ola G El-Farghali1; Ahmed Hamdy Farid2; Dina Tharwat Ghanem ![]() ![]() | ||||
1Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. | ||||
2Pediatrics Department, Faculty of Medicine, Tanta University, Tanta, Egypt | ||||
3Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||||
4Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||||
Abstract | ||||
Abstract Background: Necrotizing enterocolitis (NEC) is a life -threatening condition of the intestines that manifests solely in premature newborns. Early identification of developing NEC is still challenging, as the current radiology and laboratory tests lack sufficient accuracy. Objective: The current study aimed to assess the role of plasma D-lactate as a diagnostic and prognostic biomarker for NEC. Methods: The study encompasses 30 preterm neonates diagnosed according to clinical and radiographic criteria as NEC, in addition to 30 preterm growing neonates as matched controls. An assay of plasma D- lactate levels was done by Enzyme-linked immunosorbent assay (ELISA). Results: The plasma D-lactate levels of NEC patients were significantly higher than to those of the controls (p 0.01). The levels of plasma D lactate also showed a statistically significant increase with worse prognosis of Bell’s stage of the patients (p 0.01). The best cut-off point of D-lactate to identify cases with NEC was > 5.4 μmol/ml with diagnostic sensitivity and specificity of 100%. Conclusion: Measuring plasma D-lactate levels could be useful as a diagnostic biomarker in the early stage of NEC. Moreover, D-lactate levels can be correlated with the severity of the disease. | ||||
Keywords | ||||
NEC; neonates; D-lactate; Biomarker; ELISA | ||||
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