Role of Serum Copeptin and Ischemia-modified Albumin in Detection of Cardiac Affection in Neonatal Sepsis
El sayed, E., Hegazy, O., Habeed, N., Shehata, B. (2024). Role of Serum Copeptin and Ischemia-modified Albumin in Detection of Cardiac Affection in Neonatal Sepsis. EKB Journal Management System, 75(1), 261-274. doi: 10.21608/asmj.2024.270129.1223
Eman Mohamed El sayed; Omnia Ibrahim Hegazy; Nevin Mohamed Mamdouh Habeed; Basma Mohamed Shehata. "Role of Serum Copeptin and Ischemia-modified Albumin in Detection of Cardiac Affection in Neonatal Sepsis". EKB Journal Management System, 75, 1, 2024, 261-274. doi: 10.21608/asmj.2024.270129.1223
El sayed, E., Hegazy, O., Habeed, N., Shehata, B. (2024). 'Role of Serum Copeptin and Ischemia-modified Albumin in Detection of Cardiac Affection in Neonatal Sepsis', EKB Journal Management System, 75(1), pp. 261-274. doi: 10.21608/asmj.2024.270129.1223
El sayed, E., Hegazy, O., Habeed, N., Shehata, B. Role of Serum Copeptin and Ischemia-modified Albumin in Detection of Cardiac Affection in Neonatal Sepsis. EKB Journal Management System, 2024; 75(1): 261-274. doi: 10.21608/asmj.2024.270129.1223

Role of Serum Copeptin and Ischemia-modified Albumin in Detection of Cardiac Affection in Neonatal Sepsis

Ain Shams Medical Journal
Volume 75, Issue 1, March 2024, Page 261-274  XML PDF (653.06 K)
Document Type: Original Article
DOI: 10.21608/asmj.2024.270129.1223
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Authors
Eman Mohamed El sayed1; Omnia Ibrahim Hegazy email 2; Nevin Mohamed Mamdouh Habeed3; Basma Mohamed Shehataorcid 3
1Department of Pediatrics, Faculty of Medicine, Ain-shams University, Cairo, Egypt.
2Department of Pediatrics, Dar-Esmail Hospital, Alexandria, Egypt.
3Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Abstract
Background: Neonatal sepsis is a serious condition with increased morbidity and mortality. Cardiac complications are common sequalae for neonatal sepsis with poor prognosis. Utilization of biomarkers for early detection of these cardiac complications helps in improving the prognosis. Aim of the work: Detect the reliability of plasma copeptin and ischemia-modified albumin (IMA) as indicators of cardiac involvement in neonatal sepsis. Patients and methods: The current study included 70 preterm neonates divided into 3 groups; 30 neonates diagnosed with sepsis and cardiac affection (group 1), 20 neonates diagnosed with sepsis without cardiac affection (group 2) and 20 matched neonates free of sepsis and cardiac affection (group 3). All included neonates had a full history taking, general and local examination. In addition to measuring serum copeptin and IMA levels. Cardiac functions were assessed by transthoracic echocardiography and tissue doppler imaging. Results: A significantly higher mean value of copeptin in group 1 (12.26 ± 4.06 ng/ml), followed by group 2 (4.25±1.56 ng/ml), then group 3 (2.17±0.79 ng/ml) (p<0.001). Also, IMA was significantly higher in group 1 (263.97±81.49 ng/ml), followed by group 2 (68.62±22.08 ng/ml), then group 3 (35.94±10.94 ng/ml) (p<0.001). There was a significant positive correlation between copeptin with IMA. Conclusion: Serum Copeptin and IMA levels are good predictors for detection of cardiac complications in neonatal sepsis besides their role in sepsis detection itself.
Keywords
Neonatal; Sepsis; Cardiac; Copeptin; Ischemia-modified Albumin
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