Characterization of Doxorubicin Unknown Impurity using 1D-NMR (1H) Spectroscopy and LC-MS Mass Ionization | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 67, Issue 9, September 2024, Page 151-157 PDF (825.77 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2024.249648.8892 | ||||
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| Authors | ||||
Sridevi Somepally1; Khang Wen , Gohb2; Hari Babu Bollikolla 3, 4
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| 1aDepartment of Chemistry, Acharya Nagarjuna University, N Nagar-522 510, Andhra Pradesh, India | ||||
| 2Faculty of Data Science and Information Technology, INTI International University, 71800 Nilai, Malaysia | ||||
| 3Department of Chemistry, Acharya Nagarjuna University, N Nagar-522 510, Andhra Pradesh, India | ||||
| 4Department of Chemistry, Andhra Kesari University-523001, Ongole, Andhra Pradesh, India | ||||
| Abstract | ||||
| Doxorubicin, an anthracyline medication, is regularly used to treat a number of malignancies, including sarcoma, lung, breast, gastric, thyroid, non-Hodgkin's lymphoma, ovarian, Hodgkin's lymphoma, multiple myeloma, and childhood cancers. One unidentified doxorubicin impurity with an RRT of 1.23 and a concentration higher than 0.1% was discovered during the quality inspection of doxorubicin in bulk forms. By thoroughly analysing the 1D-NMR (1H) spectroscopic data and the LC-MS mass ionization spectrum data, the structure and molecular mass of the unknown doxorubicin impurity with an RRT of 1.23 were determined. From spectroscopic data and the LC-MS mass ionization spectrum data, it was also observed that doxorubicin and unknown doxorubicin impurity with an RRT of 1.23 are interconvertible. | ||||
| Keywords | ||||
| Doxorubicin; RRT impurity 1.26; 1D-NMR (1H); LC-MS mass ionization; Structure elucidation | ||||
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