ANNONA MURICATA LEAF EXTRACT AMELIORATES HAEMATOLOGICAL AND BIOCHEMICAL ABNORMALITIES IN TESTOSTERONE-INDUCED MALE WISTAR RAT MODEL OF BENIGN PROSTATIC HYPERPLASIA | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Volume 47, Issue 2, December 2024, Page 1311-1325 PDF (1.03 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2024.264583.2013 | ||||
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| Authors | ||||
Amanda Ezirim   1; Josephine Ezekwesili-Ofili2; Innocent Igwilo2
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| 1Department of Biochemistry, School of Biological Sciences, Federal University of Technology Owerri, Imo State, Nigeria, | ||||
| 2Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University, Awka, Nigeria. | ||||
| Abstract | ||||
| This study investigated the effects of Annona muricata leaf ethanol extract on the haematological and biochemical indices in rat testosterone-induced benign prostatic hyperplasia (BPH). Thirty male Wistar rats with average weight of 90g were divided into six groups (n=5): normal control (NC), testosterone-induced negative control (TC), Finasteride treatment control (FT; 0.5mg/kg b.w), and the A. muricata treatment low (100 mg/kg), medium (200 mg/kg) and high (400 mg/kg) b.w doses denoted as AML, AMM and AMH respectively. BPH was induced by s.c injection of testosterone propionate for 28 consecutive days. Oral treatments with finasteride and extract doses followed for 14 days. Results showed n-hexadecanoic with highest abundance (32.60%) using GC-MS. Leukocytosis, platelet aggregation, hyperlipidemia and hyperuricemia were significant observations in the TC. The extract doses significantly (p<0.05) modulated these states. This work suggests that the multiple therapeutic properties of A. muricata could serve as a safe, multifactorial treatment approach against BPH. | ||||
| Keywords | ||||
| anti-inflammatory; antioxidant; blood | ||||
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