The Diagnostic Role of CK19 and CD73 Immunohistochemistry in The Diagnosis of Papillary Thyroid Carcinoma | ||||
| Journal of Recent Advances in Medicine | ||||
| Articles in Press, Accepted Manuscript, Available Online from 14 May 2024 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jram.2024.276023.1239 | ||||
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| Authors | ||||
Nora Hamdy Elshwehy  1; Hala mohey eldin elsafy2; salah eldin sayed semary3
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| 1Demonstrator at pathology department Alazhar university (new Damietta) | ||||
| 2Professor of Pathology, Faculty of Medicine (Girls), Al-Azhar University, Cairo | ||||
| 3Assistant Professor of Pathology, Faculty of Medicine (Boys), Al-Azhar University, Damietta | ||||
| Abstract | ||||
| Abstract: Background: The presence of diagnostic doubt in specific thyroid lesions has been extensively recorded, even among pathologists with significant expertise. This is particularly true in cases of papillary thyroid cancer, where the nuclear characteristics can be unclear. Recently, numerous molecular variations in thyroid cancer have been employed to differentiate between malignant and benign thyroid tumours. CK19 and CD73 biomarkers have been successfully implemented in clinical practice, leading to a substantial enhancement in the preoperative diagnosis of thyroid cancer. Subject and and Methods: hospital-based cross-sectional study took place at Al-Azhar University Hospital, New Damietta, and Al-Zahraa University Hospital The studied cases included 60 cases of papillary thyroid carcinoma and twelve non-neoplastic cases. The presence of immunoreactivity in each marker was evaluated and scored as negative if there was no staining or weak staining in less than 10% of the cells. Any other immunoreactivity was recorded as positive. Results: CK 19 had higher sensitivity but lowest specificity than CD73. While combination had lower specificity than CK19 alone and a sensitivity of 100%. Conclusion: We could say that Ck19 or the combination of both markers could provide the best sensitivity, while CD73 provides the best specificity at 41%. | ||||
| Keywords | ||||
| Papillary Thyroid Carcinoma; CK19; CD73; Immunohistochemistry; PTC | ||||
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