Review on analytical and bioanalytical approaches for the estimation of two anti-Covid-19 drugs | ||||
| Delta University Scientific Journal | ||||
| Article 7, Volume 7, Issue 1, April 2024 PDF (542.75 K) | ||||
| Document Type: Review articles | ||||
| DOI: 10.21608/dusj.2024.250731.1039 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ekram Ahmed Ghozzy  1; Nahed Elenany2; Manar Tolba3; Samah H Abo El Abass4
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| 1Pharmaceutical Chemistry Department, Faculty of Pharmacy, Delta University for Science and Technology | ||||
| 2pharmaceutical analytical chemistry department, faculty of pharmacy, Mansoura university, Egypt | ||||
| 3pharmaceutical analytical chemistry department, faculty of pharmacy, mansoura university | ||||
| 4Pharmaceutical analytical chemistry, Faculty of Pharmacy, Mansoura university | ||||
| Abstract | ||||
| The outbreak of the COVID-19 pandemic has resulted in a significant global mortality rate. According to the World Health Organization (WHO), the virus has impacted a population exceeding 500 million people, leading to around 6.5 million deaths. The antiviral medications remdesivir and molnupiravir are pre-existing drugs that were strategically repositioned and repurposed in the context of combating the COVID-19 pandemic. The determination of these antivirals required the establishment of rapid, sensitive, precise, and reliable methodologies. The current review entails a thorough examination of various analytical methods that have been reported for the quantitative estimation of these antiviral drugs, this includes spectrophotometric, spectrofluorometric, electrochemical, and various chromatographic techniques. Those reported techniques were applied to quantify the examined antiviral medications in a single dosage, co-formulated synthetic mixture as well as in biological fluids. Therefore, the aim of this review is to highlight the current analytical techniques for the assay of both drugs. | ||||
| Keywords | ||||
| Remdesivir; Molnupiravir; Anti-viral | ||||
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