Extraction and characterization of essential oil of Lavandula dentate L: Evaluation of its cytotoxicity and anticonvulsant activities in an epileptic model | ||||
| Egyptian Journal of Chemistry | ||||
| Articles in Press, Accepted Manuscript, Available Online from 15 May 2024 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2024.280108.9524 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Aziza Anter1; Eman Abdel-Reheim2; Areej Al-Khalaf3; Abdelaziz SA Abuelsaad   4; Gaber M.G. Shehab 5; Ayman M. Abdel-Aziz 6; Mohamed Abdel-Gabbar 1
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| 1Biochemistry Department, Faculty of Science, Faculty of Science, Beni-Suef University, Beni-Suef 62521, Egypt. | ||||
| 2Physiology division, Zoology Department, Faculty of science, Beni Suef University | ||||
| 3Plant Department of Biology, College of Science, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia | ||||
| 4Immunology Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef 62521, Egypt. | ||||
| 5Department of Biochemistry, College of Medicine, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia | ||||
| 6Zoology Department, Faculty of Science, Fayoum University 63514, Fayoum, Egypt | ||||
| Abstract | ||||
| Abstract: The Labiatae (Lamiaceae, Mentaceae) plant family, includes many shrubs and herbs as well as trees and vines, is economically significant. In the present study, aerial portions of Lavandula dentata L. (1753) were collected throughout the vegetative phase and stored in the herbarium for identification, authentication, and description. The analysis was carried out utilizing gas chromatography-mass spectrometry. The quantitative data were evaluated using peak area normalization without correction factors. Moreover, in vitro, cytotoxicity assay was examined, and anticonvulsant activity was tested in vivo using an epileptic rat model. The sulforhodamine B cell cytotoxicity assay was performed in vitro to assess cellular viability or cytotoxicity produced by the ethanolic extract and oil of L. dentata against HepG2 and Vero cells. In addition, seizure intensity scores and behavioral assessments were evaluaed and revealed that both essential oil and L. dentata extract reduced seizures, decreased distance and latency time in open field experiment, increased both grooming, rearing, and frequency of ambulation. Thus, the ethanolic extract or essential oil of L. dentata influences various behavioral domains and reduces depression-like symptoms in rats by inhibiting convulsion and seizure activity. | ||||
| Keywords | ||||
| Lavandula dentate L – GC-MC – Cytotoxicity- Epilepsy- Seizure and Behavioral | ||||
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