Secondary metabolites from marine fungi as anticandidia

N. Wesa, Samuel; Hassan, Mervat Gameel; A. AboElmaaty, Sabah; A Hamed, Ahmed; Elawady, Mohamed E.; G. Hassan, Mervat; E. Elawady, Mohamed

doi:10.21608/bjas.2024.270362.1336

	Secondary metabolites from marine fungi as anticandidia
Benha Journal of Applied Sciences
Article 71, Volume 9, Issue 3, March 2024, Page 139-142 PDF (810.28 K)
Document Type: Original Research Papers
DOI: 10.21608/bjas.2024.270362.1336
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Authors
Samuel N. Wesa ¹; Mervat Gameel Hassan ²; Sabah A. AboElmaaty¹; Ahmed A Hamed³; Mohamed E. Elawady⁴; Mervat G. Hassan¹; Mohamed E. Elawady⁵
¹Botany and Microbiology Department, faculty of science, Benha University, Benha, Egypt
²Microbiology and Botany, Science , Benha University, Benha Egypt
³Microbial Chemistry department, National Research Centre, El Buhouth St. 33, Cairo, Egypt
⁴Microbial Biotechnology Department , National Research Centre , El Buhouth St. 33, Cairo 12622, Egypt
⁵Microbial Biotechnology Department, National Research Centre, El Buhouth St. 33, Cairo, Egypt
Abstract
Background: Most fungal pathogen-induced infections in humans are caused by species of Candida. Members of these species include Candida albicans, which is the most common cause of opportunistic infections. Purpose: to determine whether bioactive compounds isolated from thirteen different fungal strains have anticandida properties against a variety of Candida isolates obtained from urine and vaginal samples. The findings demonstrate a marked variation in the inhibitory responses amongst various strains of Candida, indicating a complex interaction between fungal strains and their bioactive compounds. There were clear strain-specific variations, with some fungal strains showing strong efficacy and others showing little to no inhibitory effects. Interestingly, Fungal Strain 8 continuously exhibited strong inhibitory responses, highlighting the significant influence of particular fungal strains. Different Candida isolates had varying levels of sensitivity to bioactive compounds, highlighting the need for specialized antifungal treatments. Clinical relevance can be drawn from the observed diversity in anticandida activity, which points to possible directions for the development of targeted antifungal drugs. Subsequent investigations may delve into fundamental mechanisms, pinpoint pivotal bioactive compounds, and facilitate the advancement of innovative antifungal medication discovery. Conclusion: this research provides significant understanding of the intricate dynamics of anticandida activity, laying the groundwork for future developments in specialized treatments to combat Candida infections.
Keywords
Relevant Terms: Candida albicans; marine fungi; secondary metabolites


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