Assessment of autoimmune rheumatic diseases activity during pregnancy | ||||
| SVU-International Journal of Medical Sciences | ||||
| Article 77, Volume 7, Issue 1, January 2024, Page 768-781 PDF (372.47 K) | ||||
| Document Type: Original research articles | ||||
| DOI: 10.21608/svuijm.2022.153612.1359 | ||||
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| Authors | ||||
Mai Omar Abdelaziz   1; Mohamed Ismail Abdelakareem2; Mahmoud Soliman Mawad3; Eman Ragab Abdelradi1
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| 1Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, South Valley University, Qena, Egypt. | ||||
| 2Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Al-Azhar University (Assiut Branch), Assiut, Egypt. | ||||
| 3Obstetrics and Gynecology Department, Faculty of Medicine, South Valley University, Qena, Egypt. | ||||
| Abstract | ||||
| Background:Autoimmune rheumatic diseases (ARDs) are chronic problems that disproportionately impact females of childbearing age. Objective: To evaluate the effect of pregnancy on rheumatic disease activity Patients and Methods: This prospective study was conducted on (70) pregnant patients aged from 18 to 35 years old. They were divided into four groups; (30) with Rheumatoid arthritis, (20) with SLE, (10) with Systemic Sclerosis and (10) with Ankylosing Spondylitis. Routine baseline investigations, auto antibodies and imaging. Results: There were significant differences between the current study groups as regards the history of hormonal therapy (p<0.001); family history of rheumatic disease (p=0.037). There was statistically significant higher RBCs (p<0.001), Hb (p=0.006), WBCs (p<0.001), platelets count (p<0.001) and HCT (p<0.001) value in RA patients versus other patients groups. The acute phase reactant was significant in AS patients; also both ALT and AST were significantly higher in AS patients (p<0.001). RA patients had (Anti-CCP + ) and (RF +) in 80% of cases and other 20% were negative , SLE had (ANA+ ) in all cases , Low (C3-C4) in 87.5% , (RF + ) in 12.5% of cases , in SS all cases had (ACA +) ,(Anti-SCL70 + ) and in AS all cases had (HLA-B27 +) . Conclusion: The present study pointed to the importance of tight disease control and diagnosis before and during pregnancy as well as the importance of disease activity assessment | ||||
| Keywords | ||||
| Ankylosing spondylitis; Autoimmune rheumatic diseases; Rheumatoid arthritis; Systemic lupus erythematosus; Systemic sclerosis | ||||
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