A Study of MMP-9 rs3918242 Gene Polymorphism in Egyptian Ischemic Stroke Patients | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 85, Volume 95, Issue 1, April 2024, Page 1863-1867 PDF (365.73 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2024.354958 | ||||
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| Abstract | ||||
| Background: Stroke is a complex condition influenced by various factors, with ischemic stroke (IS) having diverse etiologies and pathogenic mechanisms. Emerging evidence suggests that its development involves an interplay between genetic and environmental components. One notable genetic factor is the single-nucleotide polymorphism (SNP) rs3918242 in the MMP-9 gene, which may heighten an individual's susceptibility to IS. Objective: Toelucidate the potential association between the MMP-9 rs3918242 polymorphism and the risk of IS, while also exploring the various clinical manifestations observed among the Egyptian IS patient cohort. Materials and methods:The study recruited 70 IS patients from Benha University Hospitals, Egypt, along with 30 healthy controls. The MMP-9 gene variant (rs3918242) was analyzed using polymerase chain reaction (PCR) coupled with restriction fragment length polymorphism (RFLP) employing the SphI restriction enzyme. Results: A significant association of CT genotype (OR =3.22, 95% CI =1.68–6.18, P<0.05) with the risk to develop IS and T allele wasalso linked to an elevated risk for IS in comparison to the C allele (OR =3.35, 95% CI =2.21–5.08, P<0.05). Conclusions:The MMP-9 rs3918242 gene polymorphism is a potential risk factor for IS in Egyptians. | ||||
| Keywords | ||||
| MMP-9; Egyptian; Ischemic stroke; polymorphism; rs3918242; RFLP | ||||
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