Potential Protective Effect of Vitamin E Against Reproductive Toxicity Induced by Cypermethrin in Male Rats
Elbanna, H., Shalaby, M., Kamel, G., Galal, A., Emam, S., Khattab, M., Zakaria, A. (2017). Potential Protective Effect of Vitamin E Against Reproductive Toxicity Induced by Cypermethrin in Male Rats. EKB Journal Management System, 63(1), 83-88. doi: 10.21608/vmjg.2017.354961
Hossny Elbanna; M Shalaby; Gehan Kamel; Ahmed Galal; Shimaa Emam; Marwa Khattab; Azza Zakaria. "Potential Protective Effect of Vitamin E Against Reproductive Toxicity Induced by Cypermethrin in Male Rats". EKB Journal Management System, 63, 1, 2017, 83-88. doi: 10.21608/vmjg.2017.354961
Elbanna, H., Shalaby, M., Kamel, G., Galal, A., Emam, S., Khattab, M., Zakaria, A. (2017). 'Potential Protective Effect of Vitamin E Against Reproductive Toxicity Induced by Cypermethrin in Male Rats', EKB Journal Management System, 63(1), pp. 83-88. doi: 10.21608/vmjg.2017.354961
Elbanna, H., Shalaby, M., Kamel, G., Galal, A., Emam, S., Khattab, M., Zakaria, A. Potential Protective Effect of Vitamin E Against Reproductive Toxicity Induced by Cypermethrin in Male Rats. EKB Journal Management System, 2017; 63(1): 83-88. doi: 10.21608/vmjg.2017.354961

Potential Protective Effect of Vitamin E Against Reproductive Toxicity Induced by Cypermethrin in Male Rats

Veterinary Medical Journal (Giza)
Volume 63, Issue 1, January 2017, Page 83-88  XML PDF (3.88 MB)
Document Type: Original Article
DOI: 10.21608/vmjg.2017.354961
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Authors
Hossny Elbanna* 1; M Shalaby1; Gehan Kamel1; Ahmed Galal1; Shimaa Emam1; Marwa Khattab2; Azza Zakaria1
1Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University
2Department of Pathology, Faculty of Veterinary Medicine, Cairo University
Abstract
This study was performed to examine the possible protective role of vitamin E against insecticide Cypermethrin (CYM) in male rats. Twenty five sexually mature male rats were randomized into 5 groups: group one was kept as a negative control. In the remaining 4 groups, CYM was orally administered at groups of 15 and 7.5 mg kg (corresponding to 1/10 and 1/20 of LD50) alone and / or in combination with vitamin E for 65 successive days. Blood samples were withdrawn for estimation of testosterone, FSH and LH in the serum. Semen analysis, sex organs weights, antioxidant enzymes superoxide dismutase (SOD); glutathione eroxidase (GPx) and catalase, (CAT) enzyme activities in testicular tissue and histopathological changes in testes were the parameters used in this study. The results showed that concurrent administration of vitamin E with CYM improved the relative weight of testes and increased sperm cell concentration and percentages of sperm motility and viability. There were also significant increases in serum testosterone, FSH and LH levels and in antioxidant enzymes activity in testes. This was associated with amelioration of testicular degenerative changes.ln conclusion vitamin E exerts a protective role against testicular toxicity induced by CYM in male rats.
Keywords
Cypermethrin; Vitamin E; Male fertility; Sperms; Testosterone
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