Potential anti-obesity impact of green seaweed; Enteromorpha intestinalis | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 67, Issue 8, August 2024, Page 293-302 PDF (687.58 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2024.261129.9180 | ||||
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| Authors | ||||
Ahmed E. Elshehry1; Sally Salah2; Hanan M. L. El Gamal3; Asmaa Mohamed Abdel-Tawab  4
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| 1National Institute of Oceanography and Fisheries, NIOF,Cairo, Egypt, Marine Biotechnology and Natural Products department | ||||
| 2Nutrition and Food Safety Department, Faculty of Applied Health Sciences Technology, Pharos University in Alexandria, Egypt | ||||
| 3Nutrition and Food Safety Department, Faculty of Applied Health Sciences Technology, Pharos University in Alexandria, Egypt. | ||||
| 41- Marine biotechnology and Natural products laboratory, National institute of Oceanography and Fishers (NIOF), Egypt. 2- Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza, 12622, Egypt. | ||||
| Abstract | ||||
| Obesity is a global disease that threatens millions of people causes death every year as result of overweight complications. Furthermore, obesity is a main cause of cardiovascular disease and type 2 diabetes. Preventing and treating obesity has been a prevailing concern for many countries also the uptake of natural remedies become a primary focus of researchers to get safer and more efficient drugs. In this article we evaluate the effect of green seaweed; Enteromorpha intestinalis as a therapeutic supplement for obesity and obesity-related diseases. Female albino rats were divided into four groups; control negative (CN), control positive (CP) and positive treated with E. intestinalis crude extract (M) and spirulina powder supplement (SP). Female rats were fed by algal extract for 4 weeks and weight gain change was determined, at the end of the treatment period blood was collected and different biochemical parameters were measured to evaluate the anti-hyperlipidemic, anti-inflammatory, and antiobesity effects of the E. intestinalis crude extract compared to spirulina microalgae powder supplement on rats fed a high-fat diet. E. intestinalis extract (M) showed a significant effect in suppressing weight gain. Also, the M group showed a significant effect in suppressing plasma total cholesterol and triglycerides recording about 118 mmolL-1 and 62 mmolL-1, respectively which is nearly the same as the control negative group. Also, low-density lipoprotein, leptin, glucagon-like peptide-1 and peptide y y recorded about 60.55 mmolL-1, 8.63 mmolL-1 11.93 mmolL-1, and 102.8 mmolL-1so usage of E. intestinalis crude extract has positively effect in treatment and prevention of obesity as well as Spirulina supplement. | ||||
| Keywords | ||||
| Enteromorpha intestinalis; Spirulina; anti-obesity; anti-inflammatory | ||||
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