Topically Applied Phenytoin Gel as Adjunctive Treatment in Periodontitis Patients | ||||
| Al-Azhar Assiut Dental Journal | ||||
| Volume 7, Issue 1, April 2024, Page 9-18 PDF (1.6 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/aadj.2024.355429 | ||||
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| Authors | ||||
ibrahim hammad ibrahim  1; Abdullah Ibrahim Abd Rabbouh Ali* 2; Gamal Mohamed Soltan Zayed* 3; Bahaa Mohammed Badr* 4
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| 1Department of Oral Medicine, Periodontology, Oral Diagnosis and Dental Radiology, Faculty of Dental Medicine, Al-Azhar University, Assiut branch, Egypt. | ||||
| 2Department of Oral Medicine, Periodontology, Oral Diagnosis and Dental Radiology, Faculty of Dental Medicine, Al-Azhar University, Assiut branch, Egyp | ||||
| 3Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al-Azhar University, Assiut branch, Egypt | ||||
| 4Department of Basic Medical and Dental Sciences, Faculty of Dentistry, Zarqa University, Zarqa, Jordan Department of Medical Microbiology and Immunology, Faculty of Medicine, Al-Azhar University (Assiut branch), Assiut, Egypt. | ||||
| Abstract | ||||
| Aim: The aim of this work was to evaluate efficacy of topically applied 1% phenytoin as an adjunctive treatment in stage II grade A periodontitis. Subjects and methods: The current study was designed as a randomized controlled clinical trial performed on 60 patients of both sexes, aged from (30-52) years with stage II grade A periodontitis. Patients sites were classified into the following groups: Group I: included 30 patients treated by scaling and root planning. Group II: included 30 patients treated by scaling and root planning combined with 1% phenytoin gel application. Clinical parameters were measured at baseline, 3 and 6 months. The effect of phenytoin on vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF-BB) expression in gingival crevicular fluid (GCF) was investigated at baseline, 1, 2, 3 and 4 weeks. Results: The clinical parameters PPD and CAL showed a significant reduction in phenytoin treated sites compared with control and this reduction was considered significant at 3 months. Although phenytoin (PHT) significantly upregulated levels of PDGF-BB and VEGF in GCF than control sites within the first and second week, growth factors level decreased to nearly the base line value at 3 weeks and this reduction still to 4 weeks. Conclusion: It can be concluded that adjunctive use of 1% phenytoin gel showed a positive impact on clinical periodontal parameters in the form of probing depth reduction and attachment level gain. | ||||
| Keywords | ||||
| Periodontitis; Scaling and root planning; 1% Phenytoin gel; Platelet-derived growth factor-BB | ||||
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