High-Molecular weight Adiponectin, and TyG-BMI, are better predictive markers than TyG index and HbA1c to predict pre-diabetes in overweight adults | ||||
| Ain Shams Medical Journal | ||||
| Volume 75, Issue 1, March 2024, Page 37-46 PDF (549.58 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/asmj.2024.259915.1196 | ||||
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| Authors | ||||
Masar Hussain Ali1; Ahmed Alshawi   2
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| 1Department of MTL, College of Health and Medical Technology, Al-Furat Al-Awsat Technical University, Kufa, Iraq and Murjan Teaching Hospital, Ministry of Health, Babylon, Iraq.Murjan Teaching Hospital, Ministry of Health, Babylon; Iraq. | ||||
| 2Department of Medical Laboratory Technology, Kufa Institute, Al-Furat Al-Awsat Technical University, Kufa, Iraq. | ||||
| Abstract | ||||
| Background: The prevalence of pre-diabetes has been increased rapidly not in developing countries only. Pre-diabetes is associated with overweight. The diagnosis criteria of pre-diabetes are controversial issue. Aim of the work: The aim of this study was to establish useful parameters to predict pre-diabetes in overweigh adults. Subject and Methods: Thirty-eight adult participants were enrolled and they were divided into two groups 22 were control healthy volunteers and 16 participants were overweight. Biochemical investigations (glucose level, lipid profile), and High-molecular weight adiponectin (HMW-Adipo) hormone were done for both groups. Results: The results showed that the level of HMW-Adipo was significantly reduced in the overweight group, associated with an increase in fasting plasma glucose (FPG), triglycerides, and reduction in high-density lipoprotein (HDL-C) in the overweight group. The Pearson correlation for Triglyceride glucose- Body Mass Index (TyG-BMI), Body Mass Index (BMI), and tri-Ponderal index were positively correlated with FPG; while HMW-Adipo was negatively correlated with FPG. The area under the curve for TyG-BMI, PI and HMW-Adipo showed an excellent prediction for pre-diabetes in overweight adults. Conclusion: HMW-Adipo and/or TyG-BMI are better predictive markers for pre-diabetes adults rather than TyG-index and impair fasting glucose alone. | ||||
| Keywords | ||||
| Pre-diabetes; high molecular weight Adiponectin; overweight; Triglyceride glucose-Body mass index | ||||
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