Association of Il-6 and Il-10 Genes Polymorphisms with Breast Cancer in Egyptian Women
Badawy, A., Abdalla, H., Mahmoud, S., Elshafei, S., Eltantawy, D. (2012). Association of Il-6 and Il-10 Genes Polymorphisms with Breast Cancer in Egyptian Women. EKB Journal Management System, 32(1), 125-140. doi: 10.21608/besps.2012.35550
Abdelnaser Badawy; Hussein Abdalla; Sabry Mahmoud; Saad Elshafei; Dina Eltantawy. "Association of Il-6 and Il-10 Genes Polymorphisms with Breast Cancer in Egyptian Women". EKB Journal Management System, 32, 1, 2012, 125-140. doi: 10.21608/besps.2012.35550
Badawy, A., Abdalla, H., Mahmoud, S., Elshafei, S., Eltantawy, D. (2012). 'Association of Il-6 and Il-10 Genes Polymorphisms with Breast Cancer in Egyptian Women', EKB Journal Management System, 32(1), pp. 125-140. doi: 10.21608/besps.2012.35550
Badawy, A., Abdalla, H., Mahmoud, S., Elshafei, S., Eltantawy, D. Association of Il-6 and Il-10 Genes Polymorphisms with Breast Cancer in Egyptian Women. EKB Journal Management System, 2012; 32(1): 125-140. doi: 10.21608/besps.2012.35550

Association of Il-6 and Il-10 Genes Polymorphisms with Breast Cancer in Egyptian Women

Bulletin of Egyptian Society for Physiological Sciences
Article 9, Volume 32, Issue 1, June 2012, Page 125-140  XML PDF (376.58 K)
Document Type: Original Article
DOI: 10.21608/besps.2012.35550
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Authors
Abdelnaser Badawy* 1; Hussein Abdalla1; Sabry Mahmoud2; Saad Elshafei3; Dina Eltantawy4
1Medical Biochemistry Department, Faculty of Medicine, Mansoura University, Egypt
2General Surgery Department, Faculty of Medicine, Mansoura University, Egypt
3Histology Department, Faculty of Medicine, Mansoura University, Egypt
4Pathology Department, Faculty of Medicine, Mansoura University, Egypt
Abstract
Cytokines are factors that are known to have both tumor-promoting and inhibitory
effects on breast cancer growth depending on their relative concentrations and the
presence of other modulating factors. Genetic polymorphisms of cytokine-encoding
genes are known to predispose to malignant disease. Interleukins -10 and -6 are
crucially involved in breast carcinogenesis. The aim of this study is to evaluate the
role of IL-6 and IL-10 genes polymorphisms in the pathogenesis of breast cancer in
a case – control study of 80 females with breast cancer and 80 healthy females as
controls. Patients and controls underwent a clinical examination and finally, one ml
blood samples were withdrawn from all cases into tubes containing EDTA as an
anticoagulant for analysis of IL-6 and IL-10 genotypes. There were significant
association between C allele of the G−174 C promoter single nucleotide
polymorphism (SNP) in the IL-6 gene and breast cancer (p = 0.02). But, there were
no significant difference in IL-10 1082G→A genotypes frequency in breast cancer
when compared with normal individuals (p = 0.99). It's concluded that the CC
genotype and C allele of the G−174 C in the IL-6 gene were associated with breast
cancer in Egyptian women.
Keywords
Cytokines; IL6; IL10; Gene polymorphism; breast cancer
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