Antimicrobial resistance of multidrug-resistant Enterobacterales and Acinetobacter baumannii isolates to colistin in a Moroccan hospital | ||||
| Microbes and Infectious Diseases | ||||
| Articles in Press, Accepted Manuscript, Available Online from 21 May 2024 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mid.2024.279217.1862 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Nadia El mrimar  1, 2; El mehdi Belouad1, 2; Elmostafa Benaissa1, 2; Adil Maleb3; Mostafa Elouennass1, 2
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| 1Research Team of Epidemiology and Bacterial Resistance, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat, Morocco | ||||
| 2Department of Clinical Bacteriology, Mohammed V Military Teaching Hospital, Rabat, Morocco | ||||
| 3Laboratory of Microbiology, Mohammed VI University Hospital, Faculty of Medicine and Pharmacy, University Mohammed the First, Oujda, Morocco | ||||
| Abstract | ||||
| Background: The challenge of treating infections caused by multidrug-resistant Enterobacterales and Acinetobacter baumannii has significantly increased for medical professionals due to their resistance to conventional antibiotics. In such cases, Colistin is employed as a final line of defense. This study was aimed to determine the in-vitro efficacy of colistin against multidrug-resistant Gram-negative bacteria. Methods: The research was carried out in the Bacteriology Department of the Mohammed V Military Teaching Hospital in Rabat, Morocco. 321 isolates of multi-resistant Enterobacterales and Acinetobacter baumannii from various clinical samples were identified by standard microbiological protocols, and the Colistin minimum inhibitory concentrations value was determined using the microdilution method. Results: Of the 321 isolates included in the study, 76.3% were Enterobacterales and 23.6% were Acinetobacter baumannii. The minimum inhibitory analysis showed that 96.3% of the isolates were sensitive, while 3.7% were identified as resistant. The prevalence of resistance to colistin among multi-resistant Enterobacterales was 4.1%, and the MIC50 and MIC90 were 0.5 μg/ml and 1μg/ml respectively. Among the collected Acinetobacter baumannii isolates, the prevalence of colistin resistance was 2.6%, with the MIC50 and MIC90 of 0.5 μg/ml. Conclusion: The research indicates that colistin could be a viable treatment option for infections caused by multi-resistant Enterobacterales and Acinetobacter baumannii. | ||||
| Keywords | ||||
| Colistin; Antibiotic resistance; Multidrug-resistant Enterobacterales; Acinetobacter baumannii; Gram-negative bacteria | ||||
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