Efficacy and Safety of Add-on Treatment with Mirabegron for Benign Prostatic Hyperplasia Patients with Persistent Storage Symptoms after Alpha‌- blocker therapy.
Omar, A., Aldaqadossi, H., shaker, H., Youssof, H. (2024). Efficacy and Safety of Add-on Treatment with Mirabegron for Benign Prostatic Hyperplasia Patients with Persistent Storage Symptoms after Alpha‌- blocker therapy.. EKB Journal Management System, 13(2), 1-10. doi: 10.21608/fumj.2023.245675.1274
Ahmed Ramadan Omar; Hussein Abdel-Hameed Aldaqadossi; Hossam Ahmed shaker; Hamada Ahmad Youssof. "Efficacy and Safety of Add-on Treatment with Mirabegron for Benign Prostatic Hyperplasia Patients with Persistent Storage Symptoms after Alpha‌- blocker therapy.". EKB Journal Management System, 13, 2, 2024, 1-10. doi: 10.21608/fumj.2023.245675.1274
Omar, A., Aldaqadossi, H., shaker, H., Youssof, H. (2024). 'Efficacy and Safety of Add-on Treatment with Mirabegron for Benign Prostatic Hyperplasia Patients with Persistent Storage Symptoms after Alpha‌- blocker therapy.', EKB Journal Management System, 13(2), pp. 1-10. doi: 10.21608/fumj.2023.245675.1274
Omar, A., Aldaqadossi, H., shaker, H., Youssof, H. Efficacy and Safety of Add-on Treatment with Mirabegron for Benign Prostatic Hyperplasia Patients with Persistent Storage Symptoms after Alpha‌- blocker therapy.. EKB Journal Management System, 2024; 13(2): 1-10. doi: 10.21608/fumj.2023.245675.1274

Efficacy and Safety of Add-on Treatment with Mirabegron for Benign Prostatic Hyperplasia Patients with Persistent Storage Symptoms after Alpha‌- blocker therapy.

Fayoum University Medical Journal
Volume 13, Issue 2, April 2024, Page 1-10  XML PDF (288.44 K)
Document Type: Full Length research Papers
DOI: 10.21608/fumj.2023.245675.1274
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Authors
Ahmed Ramadan Omar email 1; Hussein Abdel-Hameed Aldaqadossi2; Hossam Ahmed shaker3; Hamada Ahmad Youssof4
1Urology department faculty of medicine fayoum university
2Urology department, faculty of medicine ,Fayoum university, Fyoum ,Egypt
3Urology department ,faculty of medicine , Fayoum university ,Egypt
4Urology department ,faculty of medicine , Fayoum university ,Egtpt
Abstract
Introduction: Benign prostatic hyperplasia (BPH) is the most common benign disease in men with various lower urinary tract symptoms (LUTS. Clinically BPH results in LUTS , which can be classified as storage, voiding, and post micturition, and often affect patients’ quality of life (QoL)
Aim of the study: The study aims to evaluate the effect of adding mirabegron for benign prostatic hyperplasia patients complaining of persistent storage symptoms after alpha-blocker therapy.
Subjects and Methods: Our prospective study included 50 male patients with persistant storage LUTS , after they were managed by a regular daily dose of α1-adrenergic receptor blockers for 4 weeks .We added mirabegron 50 mg once daily for 8 weeks .
Results: Fifty men were enrolled in this study. Mirabegron additional therapy improved the total OABSS from 8.66± 2.28 to 5.12 ± 1.85 , total IPSS from 17.98 ± 2.9 to 10.88 ±2.69 , and IPSS-quality of life (QOL) score from 5 (4- 5) to 2 (2- 3) . The voided volume (VV) and Qmax improved from 10.90 (9.60-12.13) mL/s to 14.00 (12.48-15.05) mL/s after treatment in patients overall. However, there was no significant change in PVR.
Conclusions: Mirabegron additional therapy is effective and safe for treatment of persistant storage symptoms after alpha blocker medication. , Therefore, we recommend the combination therapy of AB and mirabegron as a first-line therapy for patients with BPH who have persistent storage symptoms
Keywords : Mirabegron, Elderly male, Overactive bladder, α1-adrenergic blockers
Keywords
Mirabegron; Elderly male; Overactive bladder; α1-adrenergic blockers
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