Cellulose Sulfate: A Fascinating Anticoagulant Material | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 68, Issue 1, January 2025, Page 315-329 PDF (1.3 MB) | ||||
| Document Type: Review Articles | ||||
| DOI: 10.21608/ejchem.2024.281505.9553 | ||||
 View on SCiNiTO | ||||
| Author | ||||
Samir Kamel  
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| Cellulose and Paper Department. Chemical Industral Research Division, National Research Centre, 33 El Bohouth St. (former El Tahrir st.), Dokki, Giza,Egypt, P.O. 12622 | ||||
| Abstract | ||||
| Anticoagulants have been extensively employed in in vitro medical therapies and therapeutic procedures. In clinical applications, heparin is most frequently used, but regrettably, it has specific adverse effects, including bleeding and other drawbacks (heterogeneity and fluctuation of anticoagulant action). In addition, the isolation of heparin from animal sources increases the possibility of contamination by animal infections. Thus, the creation of heparin substitutes is a crucial area of study. One of the better options is a structurally well-defined, nonmammalian source of heparin derivative, polysaccharide sulfates being of particular interest. The most prevalent polysaccharide on Earth is cellulose. The discovery of novel uses for this adaptable material is facilitated by its inherent abundance. Cellulose can exist in different morphological forms: fiber, micro/nanocrystalline, and microfibril/nanofibril cellulose. This review extensively surveys sulfated cellulose preparation and its potential anticoagulation agent use. | ||||
| Keywords | ||||
| Heparin; Anticoagulant; Cellulose Sulfate; Acute Toxicity | ||||
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