In Vitro Assessment of a Natural Monoterpene as an Antiviral Compound against Low Pathogenic Human Coronavirus 229E | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 67, Issue 8, August 2024, Page 537-545 PDF (871.49 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2024.285388.9639 | ||||
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| Authors | ||||
Heba A. Dahdooh1; Mohamed S. Taha2; Sahar Abd Al-Daim 3; Nehal I. Ahmed3; Abdou K. Allayeh  3
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| 1Department of Chemistry of Natural and Microbial Products, National Research Centre, 12622-Dokki, Cairo, Egypt | ||||
| 2Research on Children with Special Needs Department, Institute of Medical Research and Clinical Studies, National Research Centre, 12622-Dokki, Cairo, Egypt. | ||||
| 3Environmental Virology Lab, 176, Water Pollution Research Department, Environment and Climate Change Institute, National Research Centre, 12622-Dokki, Giza, Egypt | ||||
| Abstract | ||||
| The emergence of novel viruses, including SARS-CoV-2, has highlighted the need for effective antiviral treatments. This study aimed to evaluate the antiviral potential of pine oil and α-terpineol against low pathogenic coronavirus 229E (HCoV-229E), which serves as an alternative model for COVID-19. The study investigated the virucidal, adsorption, and multiplication inhibitory effects of pine oil and α-terpineol on HCoV-229E, as well as their impact on proinflammatory gene expression in an infected human colorectal adenocarcinoma cell line. Pine oil and α-terpineol exhibited high CC50 values and moderate in vitro inhibitory activity against HCoV-229E, with selectivity indices of 8.23 and 7.7, respectively. Plaque reduction tests demonstrated that these compounds effectively suppressed HCoV-229E during the adsorption and replication stages, and they were found to reduce the expression of proinflammatory genes associated with the development of a cytokine storm. The findings of this study suggest that pine oil and α-terpineol possess significant antiviral properties against HCoV-229E and warrant further investigation as potential therapeutic agents for viral infections, including COVID-19. | ||||
| Keywords | ||||
| Pine oil; α -Terpineol compound; Antiviral activity; Low pathogenic coronavirus 229E | ||||
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