The beneficial therapeutic effects of statins, angiotensin-converting enzyme inhibitors and angiotensin-II receptor blockers on protein-C and protein-S activities in Egyptian patients with type-2 diabetes mellitus
Mohamed, E., Kareem, H., Zahran, S., El Sissy, M. (2023). The beneficial therapeutic effects of statins, angiotensin-converting enzyme inhibitors and angiotensin-II receptor blockers on protein-C and protein-S activities in Egyptian patients with type-2 diabetes mellitus. EKB Journal Management System, 33(1), -. doi: 10.4103/ejolm.ejolm_4_22
Enas M. Mohamed; Heba S. Kareem; Shaimaa M. Zahran; Maha H. El Sissy. "The beneficial therapeutic effects of statins, angiotensin-converting enzyme inhibitors and angiotensin-II receptor blockers on protein-C and protein-S activities in Egyptian patients with type-2 diabetes mellitus". EKB Journal Management System, 33, 1, 2023, -. doi: 10.4103/ejolm.ejolm_4_22
Mohamed, E., Kareem, H., Zahran, S., El Sissy, M. (2023). 'The beneficial therapeutic effects of statins, angiotensin-converting enzyme inhibitors and angiotensin-II receptor blockers on protein-C and protein-S activities in Egyptian patients with type-2 diabetes mellitus', EKB Journal Management System, 33(1), pp. -. doi: 10.4103/ejolm.ejolm_4_22
Mohamed, E., Kareem, H., Zahran, S., El Sissy, M. The beneficial therapeutic effects of statins, angiotensin-converting enzyme inhibitors and angiotensin-II receptor blockers on protein-C and protein-S activities in Egyptian patients with type-2 diabetes mellitus. EKB Journal Management System, 2023; 33(1): -. doi: 10.4103/ejolm.ejolm_4_22

The beneficial therapeutic effects of statins, angiotensin-converting enzyme inhibitors and angiotensin-II receptor blockers on protein-C and protein-S activities in Egyptian patients with type-2 diabetes mellitus

The Egyptian Journal of Laboratory Medicine
Volume 33, Issue 1, September 2023  XML PDF (57.32 K)
DOI: 10.4103/ejolm.ejolm_4_22
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Authors
Enas M. Mohamed; Heba S. Kareem; Shaimaa M. Zahran; Maha H. El Sissy
Abstract
Objectives
Patients with type-2 diabetes mellitus (T2DM) have an increased incidence of adverse cardiovascular events secondary to endothelial dysfunction, hypercoagulability, and decreased fibrinolysis. This study aimed to evaluate protein-C and protein-S activities and carotid intima-media thickness (CIMT) in patients with T2DM who were treated with statins and/or angiotensin-converting enzyme inhibitor (ACEI)/angiotensin-II receptor blockade (ARB).
Basic methods
One hundred and twenty patients with T2DM participating in the study were classified into groups based on their use of statins and ACEI/ARBs. Protein-C and protein-S activity and CIMT were compared.
Main results
Patients treated with both statins and ACEI/ARBs showed the highest levels of protein-C and protein-S activity ( < 0.001). This was followed by patients on statins alone and patients on ACEI/ARBs alone. Patients who were not on statin or ACEI/ARB therapy had the lowest levels of protein-C and protein-S activity. Moreover, we identified significant correlations between protein-C and protein-S activities and CIMT with hemoglobin A1c, cholesterol, and low-density lipoprotein.
Conclusion
ACEI/ARBs and statins have a critical impact on the hypercoagulable state characteristic of T2DM, potentially via increased levels of protein-C and protein-S activity. ACEI/ARBs also limited CIMT, an important surrogate marker for atherosclerosis.
Keywords
Carotid intima-media thickness; Diabetes mellitus; Egypt; Hypertension; Protein C; Protein S
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