Comparison between the Effects of Stem Cells and Lepidium Sativum on the Healing of Extraction Socket in Albino Rats (Histological and Immunohistochemical Study)
El-Haddad, K., Abulwafa, Z., El-Zainy, M. (2024). Comparison between the Effects of Stem Cells and Lepidium Sativum on the Healing of Extraction Socket in Albino Rats (Histological and Immunohistochemical Study). EKB Journal Management System, 7(1), 37-48. doi: 10.21608/aadj.2024.274235.1168
Khaled ES El-Haddad; Zeinab Mahmoud Abulwafa; Medhat Ahmed El-Zainy. "Comparison between the Effects of Stem Cells and Lepidium Sativum on the Healing of Extraction Socket in Albino Rats (Histological and Immunohistochemical Study)". EKB Journal Management System, 7, 1, 2024, 37-48. doi: 10.21608/aadj.2024.274235.1168
El-Haddad, K., Abulwafa, Z., El-Zainy, M. (2024). 'Comparison between the Effects of Stem Cells and Lepidium Sativum on the Healing of Extraction Socket in Albino Rats (Histological and Immunohistochemical Study)', EKB Journal Management System, 7(1), pp. 37-48. doi: 10.21608/aadj.2024.274235.1168
El-Haddad, K., Abulwafa, Z., El-Zainy, M. Comparison between the Effects of Stem Cells and Lepidium Sativum on the Healing of Extraction Socket in Albino Rats (Histological and Immunohistochemical Study). EKB Journal Management System, 2024; 7(1): 37-48. doi: 10.21608/aadj.2024.274235.1168

Comparison between the Effects of Stem Cells and Lepidium Sativum on the Healing of Extraction Socket in Albino Rats (Histological and Immunohistochemical Study)

Al-Azhar Assiut Dental Journal
Volume 7, Issue 1, April 2024, Page 37-48  XML PDF (5.53 MB)
Document Type: Original Article
DOI: 10.21608/aadj.2024.274235.1168
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Authors
Khaled ES El-Haddad email orcid 1; Zeinab Mahmoud Abulwafaorcid 2; Medhat Ahmed El-Zainyorcid 3
1Department of Oral Biology-Faculty of Dentistry -Ain Shams University, Cairo, Egypt. Department of Oral Medical Sciences College of Dentistry, Qassim University, Qassim, Saudi Arabia
2Basic and Dental Sciences Department, Faculty of Oral and Dental Medicine, Ahram Canadian University, Cairo, Egypt
3Department of Oral Biology, Faculty of Dentistry, Ain Shams University, Cairo, Egypt
Abstract
Aim: to compare the bone marrow derived mesenchymal stem cells (BM-MSCs) and Lepidium Sativum (LS) in their potential accelerating actions on the extraction socket healing in albino rats. Subjects and Methods: Forty-five albino rats had their mandibular first molar extracted and divided into 3 groups. Group (1) received no treatment, group (2) received single dose of intravenous BM-MSCs and group (3) received daily oral dose of LS extract till sacrifice. Each group was divided to 3 subgroups A, B and C according to the days from extraction to sacrifice (7, 14 and 30 days). Molar regions were processed for light microscopic examination via Hematoxylin and Eosin (H&E) and anti-osteonectin (ON) immunostain. Bone area fraction in H&E sections and the number of osteoblasts per area in ON sections were statistically analyzed. Results: All groups had proper socket healing, but group 2 had superior histomorphometric values followed by group 3. The least values were of group 1. The studied periods showed ascending bone healing values from day 7 to day 30. All differences between subgroups were statistically significant (p value < 0.05). Conclusion: Both stem cells and Lepidium Sativum have accelerating potential for the extraction socket healing with slight preference of stem cells.
Keywords
Stem cells; Lepidium Sativum; Extraction socket; bone marrow. bone healing
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