Evaluation of the antibacterial activity of a concoction made from Piper guineense (Schumach), Zingiber officinale (Roscoe) and honey on selected pneumonic bacteria in Nigeria | ||||
| Microbes and Infectious Diseases | ||||
| Articles in Press, Accepted Manuscript, Available Online from 26 May 2024 PDF (775.88 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mid.2024.274553.1833 | ||||
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| Authors | ||||
Busuyi Michael Komolafe   1; Olawale Oladejo Babayemi2; Tinuola Tokunbo Adebolu2
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| 1Training Department, Federal Road Safety Corps, Nigeria/Department of Microbiology, Federal University of Technology, Akure, Nigeria | ||||
| 2Department of Microbiology, School of Life Sciences, Federal University of Technology, Akure, Nigeria. | ||||
| Abstract | ||||
| Background: Pneumonic bacteria are bacterial species that cause pneumonia. Although, pneumonia can be treated with antibiotics however because of the problem of antibiotic resistance by many bacterial species, it’s becoming difficult to treat most bacterial infections.Therefore, the need to seek for alternative and more effective therapies is necessary. In this study, one of the traditional concoctions that is used in folk medicine to treat respiratory related diseases was examined for possible antibacterial activity on bacterial species causing pneumonia in Ondo State, Nigeria. Methods: The concoction was prepared from the seeds of piper guineense, rhizome of zingiber officinale and honey according to oral tradition. Susceptibility of the bacterial species isolated from pneumonic patients in the study area to the prepared concoction as well as conventional antibiotics was determined using agar diffusion assay.The minimum inhibitory concentration, minimum bactericidal concentration and the phytochemical profile of the prepared concoction were carried out using standard methods. Results:The in-vitro antibacterial assay of the concoction showed that it has growth inhibitory activity on the test pneumonic bacteria with zone diameter ranging from 31.25 to 37.75 mm which was superior to the one mediated by antibiotics used with zone diameter ranging from 1.25 to 16.00 mm. Phytochemicals such as saponin, tannin, flavonoid, alkaloid, terpenoid and cardiac glycosides were detected in the prepared concoction. Conclusion: The findings show that the growth inhibition mediated by the prepared traditional concoction was superior to that of the antibiotics used against the test pneumonic bacteria.Therefore it could be exploited as alternative for treating bacterial pneumonia. | ||||
| Keywords | ||||
| Traditional concoction; commercial antibiotics; Pneumonic Bacteria; antibacterial activities | ||||
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