Corn Silk Alleviates Paclitaxel –Induced Lung Toxicity in Rats.
Barakat, A., El-Nabi, S., El-Gerbed, M. (2024). Corn Silk Alleviates Paclitaxel –Induced Lung Toxicity in Rats.. EKB Journal Management System, 6(2), 182-195. doi: 10.21608/jmals.2024.356324
Aml I. Barakat; Sobhy H. El-Nabi; Mohamed S.A. El-Gerbed. "Corn Silk Alleviates Paclitaxel –Induced Lung Toxicity in Rats.". EKB Journal Management System, 6, 2, 2024, 182-195. doi: 10.21608/jmals.2024.356324
Barakat, A., El-Nabi, S., El-Gerbed, M. (2024). 'Corn Silk Alleviates Paclitaxel –Induced Lung Toxicity in Rats.', EKB Journal Management System, 6(2), pp. 182-195. doi: 10.21608/jmals.2024.356324
Barakat, A., El-Nabi, S., El-Gerbed, M. Corn Silk Alleviates Paclitaxel –Induced Lung Toxicity in Rats.. EKB Journal Management System, 2024; 6(2): 182-195. doi: 10.21608/jmals.2024.356324

Corn Silk Alleviates Paclitaxel –Induced Lung Toxicity in Rats.

Journal of Medical and Life Science
Volume 6, Issue 2, June 2024, Page 182-195  XML PDF (903.38 K)
Document Type: Original Article
DOI: 10.21608/jmals.2024.356324
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Authors
Aml I. Barakat email 1; Sobhy H. El-Nabi2; Mohamed S.A. El-Gerbed1
1Zoology Department, Faculty of Science, Damanhur University, Egypt
2Zoology Department, Faculty of Science, Menoufiya University, Egypt.
Abstract
Background: Corn silk is a yellow, silky substance that arises from the stigma of a female flower at the tip of the corn cob in the maize plant. The chemotherapeutic drug paclitaxel (PTX) is used to treat lung, esophagus, and ovarian cancer. The aim of the work: Estimate the impact of Paclitaxel (PTX) toxicity on the rat's lung and the potential protective effect of corn silk extract (CSE). Materials and Methods: The experimental groups were designed as (1) control group, (2) CSE group was given corn silk extract (CSE) (400 mg/kg) for 7 days orally, (3) PTX group was given PTX (2 mg/kg PTX (i.p) (in 0, 2nd, 4th, 6th days) and (4) PTX+ CSE group was given corn silk extract (CSE) and PTX as in the second and third groups, respectively. At the end of the experiment, the lung tissues were processed for biochemical and histological studies.
Results: The PTX-treated group possessed higher levels of MDA, NO, hydroxyproline, collagen type-1, and MMP-7 in lung tissue. Meanwhile, the concentrations of SOD, CAT, and GSH in lung tissue were decreased. Co-administration of CSE restores antioxidative systems through amelioration of the antioxidant enzyme activity in the lung tissue. In addition, histopathological changes occurred in lung tissue in the PTX-treated group. Collapsed alveoli, cellular infiltration, and perivascular fibrosis were observed. CSE administration improves lung damage induced by PTX.
Keywords
Paclitaxel- Corn silk extract; Lung- Oxidative stress - Fibrosis
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