Evaluation of Xenogeneic Bone Graft and Bone Marrow Mesenchymal Stem Cells Mixture in Promoting Osteogenesis of Jaw Bone Defects (Clinical and Radiographic study)

kamel, ahmed raky; Abdel Fattah, Ashraf; Abdullah, Abdelaziz Baiomy; Ibrahim, Arafa GadAllah

doi:10.21608/aadj.2024.273853.1167

	Evaluation of Xenogeneic Bone Graft and Bone Marrow Mesenchymal Stem Cells Mixture in Promoting Osteogenesis of Jaw Bone Defects (Clinical and Radiographic study)
Al-Azhar Assiut Dental Journal
Volume 7, Issue 1, April 2024, Page 113-122 PDF (2.15 MB)
Document Type: Original Article
DOI: 10.21608/aadj.2024.273853.1167
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Authors
ahmed raky kamel ¹; Ashraf Abdel Fattah²; Abdelaziz Baiomy Abdullah ³; Arafa GadAllah Ibrahim⁴
¹Assistant Lecturer of Oral and Maxillofacial Surgery Department, Faculty of Dental Medicine, Faculty of Dentistry, Badr University, Cairo, Egypt.
²Professor of Oral and Maxillofacial Surgery, Head of Oral and Maxillofacial Surgery Department, Faculty of Dental Medicine, Al-Azhar University – Assiut, Egypt
³Oral and Maxillofacial Surgery Department, Faculty of Dental Medicine, Al-Azhar University – Assiut, Egypt boys
⁴Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Al-Azhar University, Assuit, Egypt.
Abstract
Aim: The aim of this work was to evaluate bone regeneration capacity of Xenogeneic bone graft and Bone marrow mesenchymal stem cells (BMSCs) mixture in Osseous Jaw defects. Subjects and Methods: This study was carried out on 10 patients, aging from 15 to 50 years old, who had osseous defects due to benign tumor or large cyst ≥3cm3 by clinical and radiographic examination. All Defects were grafted with a mixture of BMSCs seeded into collagen sponge and xenogeneic bone graft. All patients were subjected to a panoramic radiograph, cone-beam computed tomography (CBCT) to assess jaw bony defect size, bone volume, and bone density. Results: The significance evaluation for volumetric changes for each time interval revealed significant difference (P < 0.05) except for immediate postoperative which were insignificant different. The significance evaluation for bone density each time interval revealed insignificant difference except for bone density change percentage which revealed significant difference (P<0.05). Conclusion: The use of autologous BMSCs seeded on gelatin scaffold combined with xenogeneic bone graft was promising for regenerating bone at odontogenic large defects ≥ 3 cm3 .
Keywords
Xenogeneic Bone Graft; Stem Cells Mixture; Osteogenesis; Jaw Bone Defects


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