Volatiles composition of fresh aroma and hydrodistilled volatile oil of Chrysopogon zizanioides roots growing in Egypt along with the cytotoxic activities of the hydrodistilled oil | ||||
Egyptian Journal of Chemistry | ||||
Volume 67, Issue 12, December 2024, Page 299-305 PDF (312.43 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejchem.2024.269434.9311 | ||||
View on SCiNiTO | ||||
Authors | ||||
Mahmoud Arafat 1; Mohammed Khalil 2; Engy A. Mahrous 3; Seham El Hawary 4 | ||||
1Pharmacognosy department, Pharmacy, Heliopolis University, Cairo, Egypt. | ||||
2Faulty of Pharmacy Cairo University | ||||
3Pharmacognosy Department, Faculty of Pharmacy, Cairo University | ||||
4Department of Pharmacognosy, Faculty of Pharmacy, Cairo University | ||||
Abstract | ||||
Chrysopogon zizanioides oil (CZO) is obtained from the roots of the C. zizanioides plant and it is frequently employed as a major odour contributor in the fragrance and aromatherapy industries. The hydrodistilled CZO was analyzed by GC/MS and compared to fresh sample aroma which was analyzed by headspace GC/MS method. The main constituents of the hydrodistilled oil were Khusimol (16.48%), aristol-1(10)en-9-ol (12.5%) and cyclocopacamphenol (7.69%). While headspace-GC/MS analysis identified bicyclo[5.2.0]nonane, 2-methylene-4,8,8-trimethyl-4-vinyl (14.17%), sativene (11.52%) and valencene (9.71%) as the major contributors to its fresh aroma. CZO was found to be active against two human cancer cell lines of lung (A549) and hepatocellular (HepG2) with IC50 32.2 and 37.6 µg/mL respectively using MTT assay. The results showed great similarity between the Egyptian oil and those available in the international market. Further studies are necessary for the full standardization and biological evaluation of the oil. | ||||
Keywords | ||||
Chrysopogon zizanioides; roots; oil; GC/MS; headspace; cytotoxic activities | ||||
Supplementary Files
|
||||
Statistics Article View: 288 PDF Download: 72 |
||||