Clomiphene Citrate versus Clomiphene Citrate in combination with other drugs in Ovulation Induction in Patients with Polycystic Ovary Syndrome | ||||
| SVU-International Journal of Medical Sciences | ||||
| Volume 7, Issue 2, July 2024, Page 1-8 PDF (199.15 K) | ||||
| Document Type: Original research articles | ||||
| DOI: 10.21608/svuijm.2023.194749.1534 | ||||
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| Authors | ||||
Mostafa Khodary1; Yasser Ahmed Abuelwafa Abdellatif   1; Mahmoud Ibrahim Almolakab B- Alrashidy2; Sayed Ahmed Mohammed Taha1
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| 1Obstetrics and Gynecology Department, Faculty of Medicine, South Valley University, Qena, Egypt. | ||||
| 2Obstetrics and Gynecology Department, Faculty of Medicine, Al-Azhar University (Assuit Branch), Assiut, Egypt | ||||
| Abstract | ||||
| Background: Polycystic ovary syndrome (PCOS) is the most prevalent cause of normogonadotrophic anovulation, also classified as World Health Organization group II anovulation. Objectives: The aim of this study was to compare the effectiveness and clinical outcomes of clomiphene citrate alone and with different combinations (metformin , tamoxifen , letrozole and low dose gonadotrophins ) in induction of ovulation in women with PCOS. Patients and methods: The Obstetrics and Gynecology department at Qena University Hospital, South Valley University, was the site of this randomized study. The study included 400 infertile cases with PCOS divided on 5 groups . The duration of the study ranged from 12-24 months. Results: In the studied groups, group 4 (clomiphene and letrozole ) and group 5 (clomiphene and low dose gonadotrophins) had the highest ovulation rate which was 31.3 % , 41.3 % respectively and also the highest pregnancy rate which was 33.8 % for each group . Conclusion: The combination of clomiphene and letrozole and clomiphene and gonadotrophins had proved to be the most effective , low cost infertility treatment in women with PCOS that offers high ovulation and pregnancy rates. | ||||
| Keywords | ||||
| Anovulation; PCOS; Clomiphene citrate; Tamoxifen; Metformin; Letrozole; Gonadotrophins; Ovulation; Induction; Endometrium | ||||
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