Regenerative Medicine for Equine Skin Wound Healing: A Review of Zinc Oxide Nanoparticles, Mesenchymal Stem Cell-Derived Microvesicles, and Propolis | ||||
| New Valley Veterinary Journal | ||||
| Article 4, Volume 4, Issue 2, June 2024, Page 23-29 PDF (116.4 K) | ||||
| Document Type: Review Articles | ||||
| DOI: 10.21608/nvvj.2024.286749.1043 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mahmoud S. Saber  1; Mohamed Wefky ElSherif 2; Mahmoud T. Nassif3
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| 1Department of Surgery, Anesthesia and Radiology, Faculty of Veterinary Medicine, New Valley University, Alkharga, New Valley 27511, Egypt. | ||||
| 2Department of Surgery, Faculty of Veterinary Medicine, New Valley University, Egypt. | ||||
| 3Department of Surgery, Anesthesia and Radiology, Faculty of Veterinary Medicine, Assiut University, Assiut 71515, Egypt | ||||
| Abstract | ||||
| Skin wound healing in animals often requires veterinary intervention with mesenchymal stem cell-derived microvesicles (MSC-MVs) emerging as a promising therapeutic avenue. MSC-MVs, minute membrane-bound structures carrying bioactive molecules, play a crucial role in influencing wound-healing processes. They modulate inflammation, which is vital for tissue repair, and stimulate the proliferation and migration of skin cells and fibroblasts, thereby facilitating tissue regeneration. Furthermore, they induce angiogenesis, which is crucial for the delivery of oxygen and nutrients to the wound site. However, realizing their potential in routine veterinary practice entails addressing current challenges. Tailored research on the optimal efficacy in target animal species is imperative because of species specificity. Determining the appropriate dosing and administration frequency for different wound types is crucial to avoid compromising the efficacy or introducing side effects. Developing efficient delivery methods suitable for diverse veterinary applications remains a priority along with standardizing production protocols to ensure consistent quality and therapeutic effects. Although generally safe, further investigation into the potential side effects, especially with prolonged use, is necessary. A cost-effectiveness analysis is essential to ensure accessibility. Future research should focus on comparative clinical trials, exploring combination therapies and targeted delivery systems, and optimizing MSC-MVs and their cargo properties. Long-term safety and effectiveness studies are vital, particularly for chronic wound management. Finally, cost-benefit analysis will determine the feasibility of incorporating MSC-MVs into routine veterinary care, potentially revolutionizing wound healing. | ||||
| Keywords | ||||
| Equine; Regeneration; Stem cells; ZnO Nano particles; Propolis | ||||
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