Evaluation the expression of Sp1 and Par3 in urinary bladder carcinoma
Fouad, E., Gharieb, S., Hanna, A., Abdelaleem, M., abozaid, E., Abdullatif, A., Fouad, E. (2024). Evaluation the expression of Sp1 and Par3 in urinary bladder carcinoma. EKB Journal Management System, 30(6), 2334-2344. doi: 10.21608/zumj.2024.284107.3347
Enass Mohammed Fouad; Shimaa Abd allah Gharieb; Amira Hany Hanna; Mohamed Abdelaleem; Eslam abozaid; asmaa Abdullatif; Enass Mohammed Fouad. "Evaluation the expression of Sp1 and Par3 in urinary bladder carcinoma". EKB Journal Management System, 30, 6, 2024, 2334-2344. doi: 10.21608/zumj.2024.284107.3347
Fouad, E., Gharieb, S., Hanna, A., Abdelaleem, M., abozaid, E., Abdullatif, A., Fouad, E. (2024). 'Evaluation the expression of Sp1 and Par3 in urinary bladder carcinoma', EKB Journal Management System, 30(6), pp. 2334-2344. doi: 10.21608/zumj.2024.284107.3347
Fouad, E., Gharieb, S., Hanna, A., Abdelaleem, M., abozaid, E., Abdullatif, A., Fouad, E. Evaluation the expression of Sp1 and Par3 in urinary bladder carcinoma. EKB Journal Management System, 2024; 30(6): 2334-2344. doi: 10.21608/zumj.2024.284107.3347

Evaluation the expression of Sp1 and Par3 in urinary bladder carcinoma

Zagazig University Medical Journal
Volume 30, Issue 6, September 2024, Page 2334-2344  XML PDF (949.16 K)
Document Type: Original Article
DOI: 10.21608/zumj.2024.284107.3347
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Authors
Enass Mohammed Fouad email 1; Shimaa Abd allah Gharieborcid 2; Amira Hany Hannaorcid 3; Mohamed Abdelaleem4; Eslam abozaid5; asmaa Abdullatif6; Enass Mohammed Fouad7
1Pathology department, zagazig univeristy, faculty of medicine,Zagazig. Egypt
2Clinical oncology zagazig university , faculty of medicine,Zagazig. Egypt
3Clinical oncology, Zagazig university, faculty of medicine,Zagazig. Egypt
4urology department, zagazig univeristy, faculty of medicine, Zagazig. Egypt
5Department of general surgery faculty of medicine Zagzig university
6pathology department. Zagazig university. faculty of medicine,Zagazig . Egypt
7pathology,faculty of medicine,Zagazig univeristy,Egypt
Abstract
Abstract

Background: Bladder carcinoma is the second most common cause of death among all genitourinary tumors. Tumor recurrence, multifocality and metastasis are main causes of related mortality The primary objective of the present study is to evaluate the expression of Sp1 and Par3 in urinary bladder carcinoma and to investigate their correlation with clinicopathological characteristics and patient survival

Patients and Methods: This prospective cohort study included 50 urothelial carcinoma cases investigated for immunohistochemical expressions of Sp1 and Par3 followed them for five years or until death. The expression of markers in all tissue samples was assessed, analyzed, and correlated with clinical-pathological parameters and outcomes.

Results: The high expression of Sp1, and low expression of Par3 was significantly associated with poor clinicopathological characteristics and unfavourable overall survival.

Conclusion: The results suggested that Sp1 and Par3 may have roles in modulation of tumor invasion. Sp1 and Par3 may serve as valuable prognostic markers or therapeutic targets for urothelial carcinoma.
Keywords
Prognosis urothelial carcinoma; mortality; metastasis
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