Impact of Porpoise Oil on Selective Biomarkers Associated with Oxidative Stress in Obesity-Induced in Rats | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 11, Volume 32, Issue 2, December 2012, Page 135-156 PDF (692.47 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2012.35854 | ||||
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| Authors | ||||
| Samia Aldardery* 1; Ayman Wagih2; Hanaa GabAllah2; Mona Abdelazeem3 | ||||
| 1Department, of Medical Biochemistry, Faculty of Medicine, Tanta University, Egypt | ||||
| 2Department, of Medical Biochemistry, Faculty of Medicine, Tanta University, Egypt | ||||
| 3Department of Histopathology, Faculty of Medicine, Tanta University, Egypt | ||||
| Abstract | ||||
| Background: Porpoise oil is yellow fatty oil obtained from porpoises. It causes a relative improvement of antioxidative defense via antioxidant enzymatic and non enzymatic mechanisms. The antioxidant role of porpoise oil is relevant to its constitution of lipid lowering effects of ω-3 polyunsaturated fatty acids) (PUFAs). Obesity has become a leading global health problem owing to its strong association with a high incidence of diseases. Oxidative stress may play a critical role in the pathogenesis and development of obesity-related diseases. Aim of the work: The aim of the present study was to evaluate the possible mechanisms of obesity-induced oxidative stress and to determine the efficacy of porpoise oil on counteracting oxidative stress induced by obesity in rats. Materials and methods: The study was carried out on 75 female albino rats which were divided into 5 groups each comprise 15 rats: group I (control non obese), group II (control obese), group III (non obese with porpoise oil administration), group IV (porpoise oil administration with induction of obesity) and group V (porpoise oil administration after induction of obesity). All groups were subjected to estimation of plasma lipid profile, plasma xanthine oxidase activity, total antioxidant capacity (TAC), hydrogen peroxide level (H2O2), and malondialdehyde level (MDA). Liver specimens were taken for histopathological examination. Results: The present study confirmed a state of dyslipidemia in obese rats manifested by significantly higher plasma levels of total triglycerides, total cholesterol, LDL-cholesterol and low levels of HDL-cholesterol as compared to the control rats. There was significant increase in MDA as well as, H2O2 levels, and xanthine oxidase activity, with significant decrease in total antioxidant capacity in control obese group as compared to the other groups. Porpoise oil treated group showed significant decrease in plasma levels of MDA, H2O2, xanthine oxidase activity, with significant increase in TAC. Also, an improvement in lipid profile and lobular architecture of the liver occurred with porpoise oil administration. Conclusion: From these results it could be concluded that obesity is a state of chronic oxidative stress and may be an inductive factor of several biochemical, metabolic alterations and also hepatic histopathological changes. Porpoise oil significantly improves the biochemical, metabolic and histopathological abnormalities induced by obesity due to its powerful lipid lowering and antiinflammatory effects and unique antioxidant properties. | ||||
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