Adipocytokines, growth factors and oxidative markers programmed Alterations in intrauterine growth retardation offspring rats with relevance of melatonin | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 16, Volume 32, Issue 2, December 2012, Page 223-244 PDF (365.64 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2012.35864 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Omyma Ahmed* ; Eman Negm | ||||
| Department of Physiology, Faculty of Medicine, Assiut University | ||||
| Abstract | ||||
| Background: Intrauterine growth restriction (IUGR) is an important perinatal problem that poses several serious short- and long-term adverse effects on health. Lead is a common environmental and industrial pollutant. Although, a variety of unfavorable effects of lead may be concerned; the knowledge about its negative developmental effects and its pathophysiological mechanisms remain uncertain. This study aimed to verify the role of adipocytokines, oxidative markers and growth factors programmed alterations in pathophysiology of IUGR induced by lead in albino rats also; to investigate the potential role of melatonin or continuous light or darkness as prophylactic against IUGR. Methods: All pregnant rats except two control groups (saline and melatonin) were given lead in drinking water throughout the pregnancy. Some pregnant rats were co-administered 10 mg/kg melatonin SC while, others were exposed to lead simultaneously with continuous darkness or light. Half of dams in each group were delivered spontaneously for following up their weight, pups weights (BW), crown-rump and tail lengths and pups survival rate after 21 days (PND21). The other half of the dams were delivered by laparotomy for detection of placenta weight and lead concentration in placenta. Results: As expected, exposure to lead resulted in decreasing all physical characters of fetus at PND 0 and 21. Of interest, melatonin supplementation or continuous darkness throughout the pregnancy ameliorated lead-induced IUGR characters. The counterbalance role of melatonin may be mediated by a significant adjustment of lead-induced alternations in the levels of adipocytokines (TNF-a, IL-6 and ghrelin) and growth factors (platelet-derived growth factor, placental growth hormone, transforming growth factor-a and insulin growth factor-1), nitric oxide and oxidative markers. Therefore, melatonin or its stimulator may represent a therapeutic option for IUGR and other perinatal complications. | ||||
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