Role Of Insulin Like Growth Factor-1 and Insulin Like Growth Factor Binding Protein-3 In Patients Of Coronary Artery Disease Attending Suez Canal University Hospital | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 21, Volume 32, Issue 2, December 2012, Page 293-308 PDF (236.83 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2012.35932 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Emad Ismail* 1; Amany El Kazaz1; Ahmed ElSerafi1; May Abd El All2; Gamela Nasr3 | ||||
| 1Medical Biochemistry Department, Faculty of Medicine, Suez Canal University, Ismailia, Egyp. | ||||
| 2Medical Biochemistry Department, Faculty of Pharmacy, 6 October University. | ||||
| 3Cardiology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egyp. | ||||
| Abstract | ||||
| Cardiovascular disease is the leading cause of mortality, not only in the Western world, but also in developing countries. It has been suggested that circulating insulin like growth factor-1 (IGF-I) and insulin like growth factor binding protein-3(IGFBP- 3) are involved in the pathophysiological processes underlying coronary artery disease. We evaluated the relationship between the levels of IGF-I and IGFBP-3 nd coronary atherosclerosis in sixty two patients attending Cardiac Clinic and Coronary Care Unit at Suez Canal University Hospital, and 30 healthy controls. IGF-1 and IGFBP-3 were measured using Immulite 1000. Fasting blood glucose and lipid profile were measured for all subjects. Coronary artery disease was more frequent among males compared to females (67.7%, and 32.3% respectively). Total cholesterol (TC), low density lipoprotein cholesterol (LDLc) and triacylglycerol (TAG) levels were significantly higher, while HDL was significantly lower in patients than controls. The means of IGF-1 and IGFBP-3 were significantly higher among control group compared to patients group (212.5 ± 109.1 ng/ml and 6.4 ± 2.3 ng/ml versus 129.5 ± 66.2 ng/ml., 4.4 ± 1.6 ng/ml respectively, p= 0.001 for each). Thirty (48.4%) of patients had 3 stenosed vessels. The mean percent of stenosis was 74.7 ± 14.2 %. IGF-1 and IGFBP-3 were lower in the group of three affected vessels but there was no significant correlation between both parameters and severity of the disease. There was significant correlation between IGF-1 and HDL (r =0.254, p-value = 0.046) in patients group while no significant correlation between IGF-1 and other parameters in both groups. There was no significant correlation between IGFBP-3 and other parameters in both groups. In conclusion, IGF-1, IGFBP-3 may be used to determine the risk of coronary artery disease in Egyptian population living in Suez Canal area. | ||||
| Keywords | ||||
| IGF-1; IGFBP-3and CAD | ||||
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