Immunohistochemical study of GATA-3 expression versus estrogen and progesterone receptor in invasive mammary carcinomas
Ismail, A., Khalifa, S., Saied, E., El-Tamamy, M. (2018). Immunohistochemical study of GATA-3 expression versus estrogen and progesterone receptor in invasive mammary carcinomas. EKB Journal Management System, 24(1), -. doi: 10.4103/kamj.kamj_31_17
Aya M. Ismail; Sara E. Khalifa; Eman M. Saied; Maha M. El-Tamamy. "Immunohistochemical study of GATA-3 expression versus estrogen and progesterone receptor in invasive mammary carcinomas". EKB Journal Management System, 24, 1, 2018, -. doi: 10.4103/kamj.kamj_31_17
Ismail, A., Khalifa, S., Saied, E., El-Tamamy, M. (2018). 'Immunohistochemical study of GATA-3 expression versus estrogen and progesterone receptor in invasive mammary carcinomas', EKB Journal Management System, 24(1), pp. -. doi: 10.4103/kamj.kamj_31_17
Ismail, A., Khalifa, S., Saied, E., El-Tamamy, M. Immunohistochemical study of GATA-3 expression versus estrogen and progesterone receptor in invasive mammary carcinomas. EKB Journal Management System, 2018; 24(1): -. doi: 10.4103/kamj.kamj_31_17

Immunohistochemical study of GATA-3 expression versus estrogen and progesterone receptor in invasive mammary carcinomas

Kasr Al Ainy Medical Journal
Volume 24, Issue 1, January 2018  XML PDF (617.81 K)
DOI: 10.4103/kamj.kamj_31_17
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Authors
Aya M. Ismail; Sara E. Khalifa; Eman M. Saied; Maha M. El-Tamamy
Abstract
Background
Estrogen receptor (ER)-positive and progesterone receptor (PR)-positive breast tumors are characterized by a gene expression profile exhibiting profound differences from that of ER and PR-negative tumors. GATA-3 gene expression is correlated with ER in breast cancer.
Aim
We aimed to evaluate immunohistochemically the expression of GATA-3 in invasive breast carcinoma, comparing this with ER and PR status and available clinicopathological features, and also to detect the association between GATA-3 and the included breast cancer molecular subtypes.
Materials
and methods Fifty invasive breast carcinomas were studied for immunohistochemical demonstration of GATA-3 in the tumor cells. Cases were classified into two equal groups: group 1, that is, ER and PR positive, and group 2, that is, ER and PR negative. Molecular subtyping was applied.
Results
GATA-3 expression was detected in 88% of cases of group 1 and 56% of cases of group 2, showing direct association with ER and PR (=0.031) and also significant association with luminal-like breast tumors. In addition, GATA-3 showed an inverse association with Ki-67 (=0.0269); however, GATA-3 failed to show significant association with any of the clinicopathological parameters.
Conclusion
GATA-3 is an important luminal marker showing strong association with ER and PR in breast cancers, suggesting being a promising new breast-specific immunomarker that could be used for detection of breast cancer origin in metastatic tumors.
Keywords
breast cancer; estrogen receptor; GATA-3; luminal breast cancer; Progesterone receptor
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