Impact of IGF-1, GH and Oxidative Stress in the Experimental Model of Juvenile and Adult Hypothyroid Retinal Degeneration | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 4, Volume 31, Issue 1, December 2011, Page 43-62 PDF (764.69 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2011.35963 | ||||
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| Authors | ||||
| Omyma Galal* 1; Effat Awad1; Amal Taha2; Faten Mahmoud3 | ||||
| 1Department of Physiology, Faculty of Medicine, Assiut University, Egypt | ||||
| 2Department of Histology; Faculty of Medicine, Assiut University, Egypt | ||||
| 3Department of Anatomy; Faculty of Medicine, Assiut University, Egypt | ||||
| Abstract | ||||
| Background: The pathophysiological mechanisms involved in hypothyroid retinal damage are still debate. Materials and methods: To study these mechanisms, ninety six pubs of albino rats were equally divided into three groups, control, hypothyroid model and thyroid supplement. Each group was separated into two juvenile and adult subgroups that were sacrificed at day 20 and 60 postnatally respectively. Pubs in hypothyroid group their mother received 0.05mg carbimazole/day/pregnant female orally during gestation and 20 days of lactation in juvenile subgroup while adult subgroup received the hypothyroid agent until day 60 postnatally. Thyroid supplement group received antithyroid agent then treated with L-thyroxine (TH) orally (10 ug/ kg body weight) for one month. Results: A significant reduction in body weight, temperature, heart rate, levels of T3, T4, GH, IGF-1, and antioxidant enzymes while increased systolic pressure and LP products were evident in hypothyroid subgroups associated with decreased in the thickness and degeneration of retinal layers. Thyroid supplementation group showed a partial normalization of the measured mediators accompanied with recovery of structural changes especially in juvenile subgroup. Conclusions: Thyroid H has a vital role in normal retinal growth. Also, GH, IGF-1, oxidative stress are significant mediators of retinal degeneration. | ||||
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