Atrial Natriuretic Peptide and Leptin in Obesity-associated Hypertension in Middle-aged Egyptian Women | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 19, Volume 31, Issue 1, December 2011, Page 271-284 PDF (251.53 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2011.35988 | ||||
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| Authors | ||||
| Mohamed Abdel-Hafez* 1; Hanan Ahmed1; Hebatallah Mostafa2; Samar Marzouk1; Marwa Ahmed1 | ||||
| 1Department of Medical Biochemistry, Faculty of Medicine, Cairo University | ||||
| 2Department of Internal Medicine, Faculty of Medicine, Cairo University | ||||
| Abstract | ||||
| Obesity is a world-wide health problem, whose incidence and prevalence are rising steadily; it may be combined with hypertension, diabetes, dyslipidemia, atherosclerosis, and/or chronic renal failure. Among these, hypertension has been observed in roughly 50% of obese individuals, which has led researchers to consider obesity as one of the most common causes of hypertension. The mechanisms linking obesity to hypertension have not been fully cleared. The present study aimed to clarify the interaction of leptin, soluble leptin receptors and the atrial natriuretic peptide in obese hypertensive patients. The study was performed on seventy five female subjects who were classified into three groups: group I (n=15) healthy lean controls, group II (n=30) obese normotensive patients, and group III (n=30) obese hypertensive patients. All participants were subjected to a thorough clinical assessment, and estimation of serum levels of glucose, creatinine, urea, cholesterol, leptin, soluble leptin receptors (sLR), and atrial natriuretic peptide (ANP). The serum levels of leptin and ANP were significantly higher in obese hypertensive and obese normotensive patients than in the controls, also, these levels were significantly higher in obese hypertensive patients when compared to obese normotensive patients. The serum sLR level in obese hypertensive and obese normotensive patients was significantly lower than in the controls, while its level in obese hypertensive patients was significantly lower than in obese normotensive patients. In the whole studied groups, the serum leptin and ANP levels were positively correlated, significantly, with BMI, diastolic blood pressure, and systolic blood pressure, but their levels were negatively correlated significantly with sLR. The serum sLR level was, significantly, negatively correlated with BMI, diastolic blood pressure, systolic blood pressure, leptin and ANP. | ||||
| Keywords | ||||
| atrial natriuretic peptide; leptin; soluble leptin receptor; Obesity; Hypertension | ||||
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