Urotensin II in the Pathogenesis of Atherosclerosis in Cholesterol Fed Rats
Tahoon, N., Zineldeen, D., El-Desuky, K. (2011). Urotensin II in the Pathogenesis of Atherosclerosis in Cholesterol Fed Rats. EKB Journal Management System, 31(1), 285-296. doi: 10.21608/besps.2011.35990
Nahid Tahoon; Doaa Zineldeen; Karima El-Desuky. "Urotensin II in the Pathogenesis of Atherosclerosis in Cholesterol Fed Rats". EKB Journal Management System, 31, 1, 2011, 285-296. doi: 10.21608/besps.2011.35990
Tahoon, N., Zineldeen, D., El-Desuky, K. (2011). 'Urotensin II in the Pathogenesis of Atherosclerosis in Cholesterol Fed Rats', EKB Journal Management System, 31(1), pp. 285-296. doi: 10.21608/besps.2011.35990
Tahoon, N., Zineldeen, D., El-Desuky, K. Urotensin II in the Pathogenesis of Atherosclerosis in Cholesterol Fed Rats. EKB Journal Management System, 2011; 31(1): 285-296. doi: 10.21608/besps.2011.35990

Urotensin II in the Pathogenesis of Atherosclerosis in Cholesterol Fed Rats

Bulletin of Egyptian Society for Physiological Sciences
Article 20, Volume 31, Issue 1, December 2011, Page 285-296  XML PDF (312.36 K)
Document Type: Original Article
DOI: 10.21608/besps.2011.35990
View on SCiNiTO View on SCiNiTO
Authors
Nahid Tahoon email 1; Doaa Zineldeen2; Karima El-Desuky3
1Department of Physiology, Faculty of Medicine-Tanta University
2Department of Biochemistry, Faculty of Medicine-Tanta University
3Department of Pathology, Faculty of Medicine-Tanta University
Abstract
Background: Atherosclerosis is the most common cause of ischemic heart diseases.
Urotensin II is the most potent vasoactive peptide discovered to date with potency
that overcomes that of angiotensin II, endothelin-1, serotonin and thromboxan A2.
Aim: This study was undertaken to evaluate the role of exogenous urotensin II in the
pathogenesis of atherosclerosis and the effect of blocking the endogenous urotensin
II. Material and Methods: 32 male wistar rat were divided into 2 groups, normal
control group (8 rats) and cholesterol rich diet group (24 rats).The latter is furtherly
subdivided into vehicle, urotensin II and palosuran groups (each is 8 rats). In all
these groups lipid profile, some inflammatory and atherosclerotic markers were
measured. Histopathological examination of tissue samples from aorta and
coronaries for atheromatous changes was also done in all groups. Results: Urotensin
II produced significant hyperlipidemia, increased CRP and SVACM-1 and decreased
NO. Foam cells and VSMC proliferation were evident histopathological findings. The
effect of urotensin II was partially reversed by palosuran. Conclusion: urotensin II is
an important mediator in the pathogenesis of atherosclerosis in hypercholesterolemic
model. Urotensin receptor blocker may be considered as an important therapeutic
target in atherosclerosis.
Statistics
Article View: 104
PDF Download: 173