The relationship between 18F FDG PET CT volumetric parameters and pathological factors in metastatic breast cancer
Husseini, M., Nasr, N., Mohamed, A., Abougabal, M. (2022). The relationship between 18F FDG PET CT volumetric parameters and pathological factors in metastatic breast cancer. EKB Journal Management System, 24(1), 39-51. doi: 10.21608/egyjnm.2022.133171.1058
Maha Abd Elkareem Husseini; Nourhan Kotb Nasr; Ahmed Abdel Hafeez Mohamed; Mahasen Amin Abougabal. "The relationship between 18F FDG PET CT volumetric parameters and pathological factors in metastatic breast cancer". EKB Journal Management System, 24, 1, 2022, 39-51. doi: 10.21608/egyjnm.2022.133171.1058
Husseini, M., Nasr, N., Mohamed, A., Abougabal, M. (2022). 'The relationship between 18F FDG PET CT volumetric parameters and pathological factors in metastatic breast cancer', EKB Journal Management System, 24(1), pp. 39-51. doi: 10.21608/egyjnm.2022.133171.1058
Husseini, M., Nasr, N., Mohamed, A., Abougabal, M. The relationship between 18F FDG PET CT volumetric parameters and pathological factors in metastatic breast cancer. EKB Journal Management System, 2022; 24(1): 39-51. doi: 10.21608/egyjnm.2022.133171.1058

The relationship between 18F FDG PET CT volumetric parameters and pathological factors in metastatic breast cancer

Egyptian Journal Nuclear Medicine
Volume 24, Issue 1, June 2022, Page 39-51  XML PDF (540.88 K)
Document Type: Original Article
DOI: 10.21608/egyjnm.2022.133171.1058
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Authors
Maha Abd Elkareem Husseini email 1; Nourhan Kotb Nasr2; Ahmed Abdel Hafeez Mohamed3; Mahasen Amin Abougabal4
1Nuclear medicine unit. Department of radiotherapy and nuclear medicine (NEMROCK) , nuclear medicine unit , Kasr Al-Ainy Hospital , Cairo University
2Nuclear medicine unit. Department of radiotherapy and nuclear medicine (NEMROCK) , Kasr Al-Ainy Hospital , Cairo University
3Oncology unit. Oncology and Nuclear Medicine Department (NEMROCK), Kasr Elainy Hospital, Cairo University.
4Professor of Nuclear Medicine Department of radiotherapy and nuclear medicine (NEMROCK) , Kasr Al-Ainy Hospital , cairo University
Abstract
Objective: Assess correlation between the 18F FDG PET/CT volumetric parameters and clinico-pathological prognostic factors in metastatic breast cancer Methods: In this prospective study we included 52 patients who underwent F18 FDG PET/CT with metastases to loco/regional lymph nodes, distant metastases were detected in 22 of them. The association of maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume (MTV), tumour/liver uptake ratio (TLR) and total lesion glycolysis (TLG) of the loco/regional lymph nodes and distant metastases with clinico-pathological prognostic factors were assessed. Results: There were significant correlations between regional lymph nodes metastases SUVmax and SUVmean and tumor grade & N stage , while no significant correlation was found regarding the other parameters including focality of the primary tumor , histology , ER , PR , HER2 , KI67 , molecular subtype and M stage. On the other hand regional lymph nodes metastases MTV, TLG and TLR, correlation was found regarding N stage only and no significant correlation was found regarding the other parameters. No significant correlations between volumetric parameters of bone metastases and clinic-pathological risk factors could be elicited. Conclusion: Volumetric parameters of the metastatic loco-regional lymph nodes in breast cancer can reflect aggressiveness of the tumor, therefore can help in therapy planes, while this not found regarding bone metastases.
Keywords
Metastatic breast cancer; PET/CT; Pathological risk factors
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