The Role Of Whole-Body SPECT/CT Using Tc-99m MDP In Characterization Of Osseous Lesions In Breast Cancer Patients
Osman, M., Eltahry, E., Fawzy, A., El-Sayed, N. (2022). The Role Of Whole-Body SPECT/CT Using Tc-99m MDP In Characterization Of Osseous Lesions In Breast Cancer Patients. EKB Journal Management System, 24(1), 52-64. doi: 10.21608/egyjnm.2022.126177.1051
Mohammed O Osman; Eman Ashraf Eltahry; Ashraf Mohy El Din Fawzy; Nahla Dessouki El-Sayed. "The Role Of Whole-Body SPECT/CT Using Tc-99m MDP In Characterization Of Osseous Lesions In Breast Cancer Patients". EKB Journal Management System, 24, 1, 2022, 52-64. doi: 10.21608/egyjnm.2022.126177.1051
Osman, M., Eltahry, E., Fawzy, A., El-Sayed, N. (2022). 'The Role Of Whole-Body SPECT/CT Using Tc-99m MDP In Characterization Of Osseous Lesions In Breast Cancer Patients', EKB Journal Management System, 24(1), pp. 52-64. doi: 10.21608/egyjnm.2022.126177.1051
Osman, M., Eltahry, E., Fawzy, A., El-Sayed, N. The Role Of Whole-Body SPECT/CT Using Tc-99m MDP In Characterization Of Osseous Lesions In Breast Cancer Patients. EKB Journal Management System, 2022; 24(1): 52-64. doi: 10.21608/egyjnm.2022.126177.1051

The Role Of Whole-Body SPECT/CT Using Tc-99m MDP In Characterization Of Osseous Lesions In Breast Cancer Patients

Egyptian Journal Nuclear Medicine
Volume 24, Issue 1, June 2022, Page 52-64  XML PDF (688.27 K)
Document Type: Original Paper, Diagnostic NM
DOI: 10.21608/egyjnm.2022.126177.1051
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Authors
Mohammed O Osman email orcid 1; Eman Ashraf Eltahry2; Ashraf Mohy El Din Fawzy3; Nahla Dessouki El-Sayed4
1Oncology and nuclear medicine department, Kasr Alainy, Cairo University
2Nuclear Medicine Department Kasr Alainy Cairo University
3Nuclear Medicine Department, Kasr Alainy Cairo University
4Nuclear Medicine Kasr Alainy Cairo University
Abstract
Introduction: breast cancer is the second greatest cause of death in women, affecting women of all ages, races, and geographical locations [1]. Bone, lungs, and liver are the most common locations of distant metastases [2]. The most extensively used approach for detecting bone metastases is whole-body bone scintigraphy with technetium99m tagged diphosphonates [4]. Objectives: Compare the rate of detectability of bone metastases in breast cancer patients utilizing whole body single photon emission computed tomography/ computed tomography against planar conventional bone scintigraphy. Material and methods: prospective study included 50 female patients diagnosed with breast cancer, with an average age of 46.9 ± 15 years. Planar bone scintigraphy was performed on the patients, followed by whole body SPECT/CT scans by administering 1110 MBq of Tc99m MDP intravenously. Full body scan was performed (table rate 12 cm/min). A total of 32 frames with 15 seconds per frame were used to collect SPECT and CT images of the entire body over a 360-degree arc with a 128*128 matrix and iterative filtration (four iterations, four subsets, and Gaussian filter 8). Both modalities were read independently by two competent nuclear medicine experts. Results: The sensitivity, specificity, positive predictive value, and negative predictive value of Planar bone scintigraphy and W.B. SPECT/CT images were 52.2 % Vs 87 %, 92.6 % Vs 96.3 %, 85.7 % Vs 95.2 %, and 69.4 % Vs 89.7 %, respectively. The difference in sensitivity between the two modalities was statistically significant (P-value = 0.001), whereas the difference in specificity was statistically inconsequential (P-value = 0.5). Conclusions: whole-body SPECT/CT bone scintigraphy improves the sensitivity of the bone scan for detecting osseous metastases and minimizes the number of equivocal lesions.
Keywords
Keywords: Bone metastases; Planar bone scintigraphy; Whole-body SPECT/CT bone
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