AN INSIGHT ON MEDICINAL ATTRIBUTES OF PHTHALAZINE SCAFFOLD, WITH A FOCUS ON THEIR ANTICANCER PROPERTIES AS VEGFR-2 INHIBITORS | ||||
| Al-Azhar Journal of Pharmaceutical Sciences | ||||
| Volume 69, Issue 1, March 2024, Page 25-37 PDF (815.83 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ajps.2024.360355 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mohammed A Dahab  ; Hatem B Bayoumi; Fathalla Khedr; Mohamed K Ibrahim
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| Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt | ||||
| Abstract | ||||
| The antitumor properties of synthetic heterocyclic compounds are among the most powerful properties that can be made use in medicinal chemistry. More specifically, their significant cytotoxic effects against many types of human tumor cells, as well as their roles as various kinase inhibitors. In recent years, Phthalazine derivatives, have frequently attracted the interest of medicinal chemistry researchers due to their promising anticancer properties. The present study is a review of the latest advances in Phthalazine derivative-related research, with a focus on their anticancer activities as VEGFR-2 inhibitors. | ||||
| Keywords | ||||
| Anticancer; Phthalazine; VEGFR-2 inhibitors; Kinase; Angiogenesis | ||||
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