Interleukin 27 Serum Level And Its Prognostic Significance In Children With Immune Thrombocytopenia | ||||
| Zagazig University Medical Journal | ||||
| Article 16, Volume 26, Issue 1, January and February 2020, Page 132-139 PDF (946.84 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2019.11145.1156 | ||||
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| Authors | ||||
Tamer hasan Hassan1; Adel Sherif ahmed1; Nermin Raafat Abdel-Fattah2; marwa ali ahmed  3
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| 1Faculty of Medicine, Zagazig University, Department of pediatrics, Sharkia Egypt | ||||
| 2Medical Biochemistry, Faculty of Medicine, Zagazig University, Egypt | ||||
| 3zagazig university faculty of medicine pediatric department,Sharkia Egypt | ||||
| Abstract | ||||
| Aim of the work: was to determine the level of IL-27 in patients with immune thrombocytopenia and its relationship to demographic,clinical and laboratory characteristics of patients as well as disease chronicity and response to treatment. Methods: A case control study carried out in Pediatric Hematology outpatient clinic , Zagazig University Hospitals. It included 80 subjects were divided into 4 group 1 included 20 patients with denovo ITP, group 2 included 20 patients with chronic ITP, group 3 included 20 patients with complete remission after 1st line therapy and group 4 (control group) included 20 healthy children as a control group. Results: there is significant difference regarding WBCs and Platelets, there was no significant difference in patients with ITP as regards hemoglobin level. ITP patients had significantly higher levels of IL-27 than controls. patients with acute ITP had the highest levels of IL-27 among patient groups ,while, patients in remission had the lowest IL-27 levels among patient groups. There was significant relationship between 1st line therapy and serum IL-27 in patients with ITP. Patients who received IVIG and combined steroids and IVIG had significantly higher IL-27 levels than others. There was significant relationship between 2nd line therapy and serum IL-27 in patients with chronic ITP. Where patients who received Eltrombopag had significantly lower IL-27 levels than others. Conclusion: we propose that the using of IL-27 as a predictor for ITP occurrence and for responsiveness to treatment but this need to be confirmed in larger studies. | ||||
| Keywords | ||||
| Immune thrombocytopenia; Interleukin 27; Interleukin 27 in immune thrombocytopenia | ||||
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