Effect of N-acetylcysteine on Hepatic Ischemiareperfusion Injury in Normal and Steatotic Rats | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 3, Volume 31, Issue 2, June 2011, Page 37-48 PDF (266.28 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2011.36086 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Nahid Tahoon  ; Ahmed Abdalfattah
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| Department of Physiology, Faculty of Medicine, Tanta University | ||||
| Abstract | ||||
| Background: Liver ischemia-reperfusion (I/R) injury occurs during major liver surgery, transplantation or following haemorrhagic shock with subsequent fluid resuscitation. Liver steatosis is a risk factor in liver transplantation and liver resection. Aim: This study was undertaken to evaluate the effect of N-acetylcysteine (NAC) on hepatic I/R injury in both normal and steatotic rat livers. Material and methods: 48 male wistar rats, divided into 2 equal groups, steatosis was induced in one of them by high cholesterol diet for 8 weeks. Each of these 2 groups was subdivided into 3 subgroups; control, I/R, I/R+ NAC groups. At the end of experiment, liver enzymes, inflammatory, lipid peroxidation and oxidative parameters were assessed and histopathological examination of liver samples was done to prove the incidence of steatosis. Results: NAC produced significant reduction in liver enzymes, inflammatory, lipid peroxidation parameters and significant increase in antioxidant parameters in both normal and steatotic rats. Conclusion: NAC may be considered as a promising therapeutic candidate for chemoprevention of hepatic I/R injury through its antioxidant, anti-inflammatory, antifibrotic, antiapoptic and antisteatotic effects in either normal or steatotic livers. | ||||
| Keywords | ||||
| Ischemia-reperfusion; N-acetylcysteine; steatosis | ||||
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