Protective Effect of Propolisagainst Osteoporosis in Rat Model | ||||
Bulletin of Egyptian Society for Physiological Sciences | ||||
Article 4, Volume 31, Issue 2, June 2011, Page 49-62 PDF (291.91 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/besps.2011.36090 | ||||
View on SCiNiTO | ||||
Authors | ||||
Faten Abd El Hadya 1; Mohga Abdallah2; Rokia El-Banna3; Hatem El-Mezayen2; Safinaz Sayed4; Laila Ibrahim1 | ||||
1Department of Chemistry of Natural Products, National Research Center, Egypt | ||||
2Department of Chemistry (Biochemistry devision), Faculty of Science, Helwan University | ||||
3Department of Biological Anthropology, National Research Center, Egypt | ||||
4Department of Histology, Faculty of Medicine, Cairo University | ||||
Abstract | ||||
Osteoporosis is a global problem that affects adversely the post-menopausal women and elderly men as well. It is defined as a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to enhanced bone fragility and consequent increase in fracture risk. The present study aimed to evaluate the effect of Egyptian propolis in the prevention of osteoporosis induced by ovariectomy (OVX) in rats. The biochemical, bone mineral density (BMD), histopathological, morphometric and scanning electron microscopic (SEM) analyses of treated animals were performed. The increase in BMD, serum calcium (Ca), femur shaft width and decrease in serum osteocalcin, alkaline phosphatase, tartrate-resistant acid phosphatase, urinary Ca levels are higher in rats treated with propolis than those of OVX group, which indicate marked restorative action. SEM study revealed porous and erosive appearance of femur bone at the epiphyseal region, shaft and head in the OVX rats when compared with sham operated rats. Treatment with propolis decreased the resorption and maintained the intactness andintegrity of the femur surface indicating its usefulness in the prevention of bone loss. | ||||
Keywords | ||||
Osteoporosis; Ovariectomy; Propolis; BMD; SEM | ||||
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