Sensitivity of Biomarker: Leptin, Adiponectin or High Sensitivity C-reactive protein in diagnosis of Coronary Heart Disease | ||||
Bulletin of Egyptian Society for Physiological Sciences | ||||
Article 11, Volume 31, Issue 2, June 2011, Page 143-156 PDF (239.74 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/besps.2011.36128 | ||||
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Authors | ||||
Samir Mahgoub* 1; Tarek Abdelrahman2 | ||||
1Department of Biochemistry , Faculty of Medicine, Al- Minia University | ||||
2Department of Cardiology, Faculty of Medicine, Al- Minia University | ||||
Abstract | ||||
Background: Adipose tissue is known to produce and release numerous bioactive substances, known as adipokines (such as leptin and adiponectin), which have been found to be involved in various physiological processes, including the regulation of arterial tone. Also, high sensitivity C-reactive protein (hs-CRP) is related to cardiovascular risk factors and adipokines. Methods: Forty patients with established coronary heart disease (CHD) defined as old myocardial infarction & angina pectoris classified as CHD group and ten normal healthy subjects classified as the control group participated in the present study. All patients and controls were subjected to complete clinical history taking, clinical examination including 12 lead electrocardiogram (ECG), diagnostic coronary angiography (CA) and the measurement of serum levels of triacylglycerols (TGs), total cholesterol (total-C), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), leptin, adiponectin and hs-CRP. Results: Serum levels of leptin, hs-CRP, LDL-C and total-C showed highly significant (p< 0.0001) increase, while, adiponectin levels showed highly significant (p< 0.0001) decrease in the group of patients when compared to the levels of the control group. The levels of HDL-C in the group of patients were significantly (p< 0.05) lower than in the control group. There was no significant difference between the levels of TGs in the patients versus the controls. Leptin was weakly correlated positively with hs-CRP, while, nonsignificantly correlated negatively with adiponectin. Hs-CRP was moderately correlated negatively with total-C. The overall positive rates obtained from Receiver operating characteristic (ROC) curve for evolution of sensitivity and specificity of the different biomarkers is obtained. The sensitivity was 100% for both leptin and adiponectin, but, it was 75% for hs-CRP. ROC curve results revealed that the specificity for leptin, adiponectin and hs-CRP were 100%, 90% and 80%, respectively. Conclusion: The results obtained in the present study reveals that serum leptin, adiponectin and hs-CRP might play an important role in the pathogenesis of CHD and the circulating levels of leptin and adiponectin provide highly sensitive and specific biomarkers for CHD more than hs-CRP. | ||||
Keywords | ||||
adiponectin; leptin; CRP; Coronary heart disease | ||||
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